Male 66 years

Treated with intravesicular BCG for TCC bladder (no recurrence). Developed fever & night sweats and abnormal LFTs (only on one occasional was ALT increased, rest returned to normal). EMU - mycobacterium identified as BCG (no positive culture from blood on liver)

Specimen: Liver core biopsy

Macroscopic description: 4 mm core, brown (other half submitted to microbiology)

Male 49 years

Matched unrelated bone marrow transplant for acute myeloid leukaemia seven months previously. HCV RNA detected on PCR. Alcohol 2 units/day. 750 units of blood transfused over course of leukaemic disease (which followed two courses of chemoradiotherapy to obtain remission). On Cyclosporin, Acyclovir, Co-Trimoxazole. Had had GvHD when CYA reduced early, now no evidence clinically. Previously noted to have a liver mass which melted with chemoradiotherapy so was assumed to have been a chloroma. Now ALT 433, ALP 153, GGT 48, bilirubin 15, Alb 41, INR 0.9

Specimen: Liver core biopsy

Macroscopic description: Two cores measuring 28 mm and 14 mm long

Female 44 years

Hepatitis. CMV positive. Hepatitis B negative. ANA positve. Antimitochondrial Ab positive

Specimen: Liver needle biopsy

Macroscopic description: Core of green and tan tissue 16 mm long.

Female 59 years

6 months history of itching. Weight loss, hepatomegaly, negative liver screen. MR - small vessel Budd Chiari.

Specimen: liver biopsy

Macroscopic description: one core 18mm

Female 39 years

Recurrent liver cyst excised - stroma shows nuclear positivity for oestrogen and progesterone receptors.

Specimen: Resection of liver cyst

Macroscopic description: Liver measuring 17 x 9.5 x 2cm with attached large opened thick walled cystic structure measuring 14.5 x 9 x 6cm.

Male 12 years

Abnormal LFTs, for investigation, ?autoimmune liver disease. Specials: Reticulin - extensive collapse, Orcein - no mature fibrosis, no copper associated protein.

Specimen:

Liver biopsy

Macroscopic description: Pale tan core measuring 2.3cm.

Female 57 years

Asymptomatic gamma GT: 162 iu/l (12-43). Alk phos 174, bilirubin 7. ANA negative. AMA positive. M2 positive. Viral hepatitis serology negative IgM 3 g/l (0.5 - 2.0) Microphotographs CK7 and Orcein (see website).

Specimen:

Core biopsy

Macroscopic description: Two cores each measuring 15mm in length.

Female 57 years

? Fluclox-hepatitis. Raised ALT 1000, raised ALP and bilirubin. Virus negative.

Specimen: liver biopsy

Macroscopic description: one core 15mm.

Male 22 years

Leg rash, abnormal immune markers (elevated IgG, ANA+), inflammatory bowel disease. INR 1.2

Specimen: Liver core biopsy

Macroscopic description: two cores up to 15mm in length.

Male 66 years

First presentation of abnormal LFTs. Poorly defined lesion on CT - guided biopsy.

Specimen:

Liver biopsy

Macroscopic description: Three tan cores of tissue measuring 16, 17 x 14mm in length x 1.5mm.

Male 55 years

Abnormal LFTs, for USS guided liver biopsy, low platelets. Lesion noted on previous abdominal USS appeared to increase in size. ?tumour. Immunohistochemistry CD13, pCEA, CD10 and ubiquitin positive

Specimen:

Liver biopsy

Macroscopic description: Two cores each measuring 0.5cms.

Male 30 years

Ex-intravenous drug user. Hepatitis C. Nil else on special stains. No further clinical details.

Specimen:

Liver biopsy

Macroscopic description: Single core of tan tissue measuring 14 mm in length.