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Teaching

16th & 17th June 2016 - Problems in Tumour Pathology Course

The Christie NHS Foundation Trust, Manchester, UK







Dr. Sudha Desai :: Case 1

Female 66 years

Uterine mass ?Sarcoma. Macro: The fundus contains an intramyometrial grey/white tumour mass measuring 70 x 63 mm.


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Dr. Sudha Desai :: Case 2

Female 46 years

Uterine mass ?Sarcoma. Macro: The myometrium is distended by a nodular, grey, fleshy and mucoid tumour and measures 55 in diameter. It extends into the parametrial tissue.


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Dr Daisuke Nonaka :: Case 1

Female 67 years

Underwent a right hemi-thyroidectomy, which showed a near complete replacement of the lobe by a complex mass (4.5cm).


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Dr Daisuke Nonaka :: Case 2

Male 71 years

Presented with a right neck lump (1.5cm). Excision biopsy was performed. He had a number of imaging studies, including CT thorax, abdomen, pelvis, temporal bones and PET CT. All of them were negative. A few months later chest CT showed a nodule in the right lower lobe of the lung, with an enlarged subcarinal lymph node suspicious for metastasis. H&E slide is a representative section from the right neck lump.


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Dr Bipasha Chakrabarty :: Case 1

Male 47 years

Extensive peritoneal metastases and ascites. Suspected ? appendiceal ? colonic primary tumour. Peritoneal nodule for histology.


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Dr Bipasha Chakrabarty :: Case 2

Male 47 years

Whilst investigating for weight loss and an elevated PSA, CT scan identified mucinous ascites with features consistent with PMP. Laparotomy performed. Showed "mucinous mass in RIF (? related to appendix) with numerous nodules in the small bowel mesentery, on the colonic epiploicae and in the greater omentum". Right hemicolectomy/omentectomy performed which showed an ill-defined, gelatinous mass that encased part of the colon and small bowel and appeared to replace the omentum. Section from the mass.


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Dr Michael Tetzlaff :: Case 1

Male 73 years

Followed up by his primary care physician and dermatologist for an area on the scrotum for over 2years. Originally, patient was treated on and off with cortisone cream for ? fungal lesion. The lesion worsened with this treatment. More recently the patient was given a 7 day trail of an oral antifungal agent. Again, the lesion showed no evidence of improvement. The patient underwent a biopsy of the right scrotum.


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Dr Michael Tetzlaff :: Case 2

Male 65 years

Developed an elevated skin lesion on his shoulder that subsequently started changing in colour and size. Specifically, it became darker brown and began to enlarge with irregular borders. He thought that he had a boil and tried to treat the lesion with home remedies. However, when it continued to be concerning without improvement, he went to his dermatologist for a biopsy.


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Dr Anais Malpica :: Case 1

Female 53 years

Oriental female with a 6 month history of irregular uterine bleeding, had a PAP smear which was interpreted as HSIL. No high risk HPV was detected by Hybrid Capture Test. Endocervical curettings and endocervical and endometrial biopsies were obtained and the diagnosis of small detached fragments of dysplastic squamous epithelium with either LSIL or favour HSIL was rendered. The patient was scheduled for surgery. Then, she was found to have a positive pregnancy test. Her β-hCG was 155mIU/mL. The patient underwent a cold knife cone which was followed by a robotically assisted hysterectomy. The 12 x 9 x 6 cm uterus had an ill-defined, polypoid mass extending from the fundus to the cervix and invading the full thickness of the myometrium at the level of the lower uterine segment. The tumour extended to the scanty attached parametrial tissue and a separately submitted vaginal margin. The patient received 6 cycles of TPTE (alternating Paclitaxel/Cisplatin and Paclitaxel/Etoposide). Her β-hCG decreased to 2.9 mIU/mL and her PET/CT showed no evidence of disease. Eight months later, her β-hCG started to increase and her imaging studies showed foci of peritoneal and liver disease. She underwent resection of the liver and small bowel tumour.


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Dr Anais Malpica :: Case 2

Female 57 years

African-American, postmenopausal and obese, presented with a left sided non-tender, soft vulvar mass which had been enlarging over a 4 year period. Physical examination revealed a pink, soft, probably fluid-filled mass measuring approximately 11 cm in length and 5 cm in width. USS showed that the mass had cystic and solid areas and no increased blood flow. She had a wide local excision and the specimen contained a well demarcated, fatty, slightly fibrotic, 6.7 x 5.5 x 5.2 cm mass.


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Dr Melissa Taggart :: Case 1

Female 58 years

Liver tumour. Right hepatectomy performed.


Dr Melissa Taggart :: Case 2

Male 60 years

Right sided intestinal tumour. Right hemicolectomy performed.


Dr Cesar A Moran :: Case 1

Male 57 years

Presented with dyspnea and chest pain of several weeks. Diagnostic imaging showed an ill-defined tumour involving the pleura. Thoracotomy was performed with a surgical resection of the tumour mass.


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Dr Cesar A Moran :: Case 2

Female 43 years

Presented with cough, chest pain and dyspnoea. Diagnostic imaging revealed a centrally located intrapulmonary tumour mass. Lobectomy was performed.


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Dr Patrick Shenjere :: Case 1

Female 52 years

Presented with non-specific abdominal symptoms and menorrhagia. She described occasional mild abdominal distension, a sensation of bloating and feeling nauseated. Diagnostic imaging showed 15cm tumour involving the transverse colon wall and mesentery. Subtotal colectemy performed.


Dr Patrick Shenjere :: Case 2

Female 20 years

Large intra-abdominal mass involving large bowel wall, omentum and right ovary. Debulking performed.


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