JISC case 00108

Female, 28 years old
Clinical details:
Patient complained of pain and swelling of left lower thigh following mild trauma 5 weeks previously. The lower half of the femur was enlarged with hard rounded masses outside and connected with bone. This was very tender. Following biopsy, a hindquarter amputation was performed. 3 months. later there was x-ray evidence of lung metastases. Death occurred 11 months. following initial trauma, with painful deposits in the spine. No P.M. Section of femur showed soft, yellowish tumour occupying the medulla of the lower half of the bone, and also rounded whitish encephaloid masses external to the bone and adherent to it.
Diagnosis:
Sections show the characteristic appearance of a liposarcoma with transitional areas between well-differentiated malignant fatty tissue and undifferentiated spindle-cell growth.
Review diagnosis:
Liposarcoma.
System:
Soft Tissue and Bone
Specimen:
Excision
Date:
p1955

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