Female 86 years

Solid mass.



Specimen: TURBT.

Macro: Approximately 2grams of tissue fragments (all taken in one block).

Immunohistochemistry:
None.

Male 35 years

Tumour upper pole of right kidney.



Specimen: Right partial nephrectomy.

Macro: 26g partial nephrectomy 50 x 40 x 23mm with well circumscribed tumour 26mm in maximum diameter.

Immunohistochemistry:
CD10, RCC, TFE3 positive. CAM5.2, CK7 and AE1/3 negative.

Male 72 years

Muscle invasive bladder cancer. Laproscopic radical cystoprostatectomy.



Specimen: Cystectomy.

Macro: White nodular tumour invading upper/anterior bladder wall.

Immunohistochemistry:
None.

Male 34 years

Left testicular tumour. AFP 11.1, beta HCG 124, LDH 309.



Specimen: Testis.

Macro: Testis 7.5 x 6 x 4 cm with 7.5cm x 3.4cm cord. The testis contains an ill defined pale tumour with areas of haemorrhage confined by the tunica.

Immunohistochemistry:
CD30 and OCT3/4 positive. Focal AFP and HCG positivity.

Female 58 years

Patient previously had biopsies of urethral tumour, found within a urethral diverticulum. Now anterior pelvic clearance.



Specimen: Transverse section (one representative half of megablock) of urethra from anterior pelvic clearance.

Macro: The urethra is dilated up to 30 mm diameter and filled by a tumour (arising within a urethral diverticulum). Focally the tumour erodes through the anterior vaginal wall.

Immunohistochemistry:
CK7 positive, PAX8 positive, CK20 stains very rare cells only. Ki67 stains 25% of nuclei. GATA3 negative, p63 negative.

Male 60 years

Right nephroureterectomy for ureteric tumour lower half of ureter with a right hydronephrosis and minimal cortex.



Specimen: Nephroureterectomy.

Macro: Right nephrectomy specimen with peri-renal fat: 210x130x90mm, and including 165mm of ureter. The mid 80mm of ureter appears thick-walled. The specimen in total weighs 738g. On opening, the kidney itself measures 105x60x20mm. The adrenal is not present. The kidney shows a hydronephrosis and marked cortical atrophy. The renal pelvis and proximal ureteric mucosa appear normal. A surgical clip is present approximately one third of the way down the ureter. On opening, the thickened ureter shows apparent luminal papillary tumour.

Immunohistochemistry:
N/A.

Male 20 years

Thick, nodular and cartilaginous hydrocoels sac wall ?TB.



Specimen: Hydrocoele sac wall.

Macro: 2 pieces of firm pale tissue together measuring 64 x 55 by up to 9 mm. One surface is pale and nodular, the other surface is smooth, pale and slightly congested.

Immunohistochemistry:
Vimentin, pan cytokeratin and desmin positive with focal weak expression of CD99 and WT1 negative.

Female 51 years

Right renal tumour, extending into inferior vena cava and involving paracaval lymph nodes.



Specimen: Radical nephrectomy.

Macro: Kidney showing tumour, 13.5cm diameter, involving renal vein.

Immunohistochemistry:
CD10 negative, CK7 very occasional cells positive, vimentin positive, AMACR positive.

Male 38 years

Incidental retroperitoneal lymphadenopathy. Lymph node biopsy: mature teratoma.



Specimen: Right Radical Orchidectomy.

Macro: Testis, spermatic cord with coverings 45 x 27 x 25mm and cord 75mm. No abnormality on external examination. Slicing reveals a scar-like area 10 x 5mm towards lower pole. No other abnormality.

Immunohistochemistry:
None.

Male 68 years

BPH and acute retention.



Specimen: TURP.

Macro: Prostatic chippings - multiple pieces of prostatic chippings together weighing 40g.

Immunohistochemistry:
Tumour shows strong positivity with P63 and shows positivity with MNF116 and 34Be12. The tumour cells are negative with chromogranin, PSA, CD56 and synaptophysin.

Male 68 years

Presented with shortness of breath - on investigation R Pleural effusion and mass R kidney found.



Specimen: R kidney + hilar nodes.

Macro: Kidney 102 x 57 x 42mm.There is a white mass with nodular cut surface at the lower pole measuring 39 x 27mm. Hilar nodes appear grossly replaced by tumour.

Immunohistochemistry:
Positive for CD10, vimentin, P504S, E-cadherin, PAX8 Oct 3/4. Negative for 34BeE12, p63, CD117.

Male 43 years

Testicular tumour.



Specimen: Left testis.

Macro: A radical orchidectomy specimen with the testis and epididymis measuring 60x40x25mm. The attached spermatic cord measures 75mm length. On sectioning the testis, there is a multifocal pale solid tumour measuring 25mm aggregate. There is an area of haemorrhage and necrosis within the central tumour. The tunica and cord appear free of tumour.

Immunohistochemistry:
None done.

Male 80 years

PSA 3.5. DRE Left positive. Clinical stage T3b.



Specimen: Right Apex.

Macro: Right Apex Cores.

Immunohistochemistry:
Racemase (red), p63/34BE12 Cocktail.

Male 63 years

Previous radiotherapy for Gleason 4+4, rising PSA now to 4.2.



Specimen: Prostate core - Right apex.

Macro: Right apex cores.

Macro: None.

Male 65 years

PSA 3.6, DRE - firm Volume - 36cc.



Specimen: Prostate core - left apex.

Macro: Left apex.

Immunohistochemistry:
None.