Male 43 years

Left testis tumour. LDH raised. Multiple mets.



Specimen: Left testis.

Macro: Left radical orchidectomy. Size of testis: 17 x 13 x 11 cm. Size of tumour: 13.5 x 12 x 12 cm. Solid, yellow tumour with necrosis.

Immunohistochemistry:
reveals strong positivity for inhibin, Calretinin, Melan-A and vimentin. Germ cell tumour markers (OCT3/4, SALL4, HCG, AFP, Glypican 3), epithelial markers and S-100 are negative. The Ki-67 proliferation rate is approximately 5-10%.

Male 80 years

Biopsy proven TCC right ureter -poorly functioning kidney - right nephrouretectomy.



Specimen: Nephrouretectomy.

Macro: 402 g specimen of kidney with fat overall 135 x 55 85 mm with 180 mm ureter, the kidney itself 97 x 60 x 40 mm. No residual ureteric lesion seen macroscopically. Only finding was incidental 10 x 7 mm well circumscribed yellow lesion renal cortex showing focal haemorrhagic areas. (Note - no residual TCC either macroscopically or microscopically in ureter- presumed removed by previous biopsy).

Immunohistochemistry:
Vimentin, CD10, CK7, RCC, Carbonic anhydrase, EMA - positive.

Female 54 years

Haematuria. Irregular trigonal area.



Specimen: Urinary bladder biopsy.

Macro: Two fragments of tissue measuring 4mm in maximum dimension each.

Immunohistochemistry:
None.

Male 78 years

Papillary growth in prostatic urethra extending into prostate. PSA 43 ? Ca prostate ? TCC of prostatic urethra.



Specimen: TURP.

Macro: Prostate chips weighing 75g.

Immunohistochemistry:
PSAP strongly positive, PSA weakly positive.

Male 44 years

Abnormal refills identified on flexible cystoscopy.



Specimen: Urinary bladder biopsy.

Macro: Two fragments of tissue measuring 3 and 4mm.

Immunohistochemistry:
None.

Male 81 years

Right renal tumour.



Specimen: Right partial nephrectomy.

Macro: A partial nephrectomy specimen measuring 50 x 45 x 21 mm. On sectioning, there is a dark brown, well circumscribed tumour mass measuring 23 x 19 x 16 mm.

Immunohistochemistry:
Diffuse membranous staining for CD117, CK 7 mainly negative, CD 10 negative, vimentin negative. Hale's colloidal iron stain equivocal.

Male 64 years

Haematuria; CTU showed bladder diverticulum confirmed on cystoscopy.



Specimen: TURBT.

Macro: Several tan coloured fragments, measuring in aggregate 25 mm across.

Immunohistochemistry:
None.

Male 22 years

Mass in left testis.



Specimen: Left Orchidectomy.

Macro: Testis measuring 50x40x35 mm with attched spermatic cord measuring 65 mm in length x up to 25mm. Slicing the specimen reveals a solid pale brown tumour that measures 35x25 mm.

Immunohistochemistry:
N/A.

Female 81 years

Bladder tumour.



Specimen: TURBT.

Macro: Grey brown fragments weighing 6 gram.

Immunohistochemistry:
CEA +ve, CK7 +ve, CDX2 positive, CK20 +ve, CD15 positive and thrombomodulin negative.

Male 44 years

Right upper pole tumour.



Specimen: Right radical laproscopic nephrectomy.

Macro: 82mm sized upper pole solid brown lesion. No scarring seen. No involvement of renal vein or extension into capsular fat or sinus fat.

Immunohistochemistry:
Tumour shows diffuse CK7 positivity, CD10 is negative.

Male 68 years

History of high grade bladder cancer ? Recurrence.



Specimen: TURBT.

Macro: Multiple fragments 2 gm.

Immunohistochemistry:
None.

Male 71 years

Robotic radical prostatectomy, PSA 10.5, Gleason 3+4 on biopsy.



Specimen: Radical prostatectomy.

Macro: Radical prostatectomy - 71grams. Cruciate block from base margin.

Immunohistochemistry:
None.