Male 49 years

History of left orchidectomy. Suspicious lump in right testis.



Specimen: Right testis.

Macro: Right testis measuring 65 x 40 x 45 mm with intact vaginal sac and 25 mm spermatic cord attached. Sectioning reveals a solid and cystic tumour measuring 40 x 30 x 40 mm confined within the tunica albuginea.

Immunohistochemistry:
GFAP and NSE highlighted glial tissue and neurons. OCT3/4 and Myogenin negative.

Female 73 years

Left open radical nephrectomy + hilar nodes. Appendicectomy. Had pelvic collection.



Specimen: Left open radical nephrectomy for renal mass.

Macro: Left kidney: A kidney measuring 20cm superior to inferior x15cm medial to lateral x 14cm anterior to posterior. There is a segment of ureter measuring 6x0.5cm. There is tumour measuring 15x11x9cm, involving most of the kidney, which appears to be confined to the kidney. Large areas are necrotic. There is no macroscopic involvement of the renal vein.

Immunohistochemistry:
tumour is diffusely positive for WT1, CD57 and PAX8 with scattered focal positivityfor CD56 (NCAM). EMA shows only extremely scanty focal positivity at one edge of the lesion but is negative elsewhere. CK7, racemase (AMACR), TTF-1 and CAIX are negative.

Male 65 years





Specimen: Bladder biopsy.

Macro: Tissue 6mm maximum.

Immunohistochemistry:
None performed.

Male 31 years

End stage renal failure on dialysis. Acquired cystic kidney disease and had been followed up. On last scan a more solid lesion was seen.



Specimen: Left nephrectomy.

Macro: Atrophic and scarred kidney with multiple cysts, 5-35mm in size. Within the largest cyst was a solid lesion, 18mm, which is represented on submitted section.

Immunohistochemistry:
None.

Female 53 years

Large 2cm polyp bladder neck, narrow stalk ?benign inverted papilloma.



Specimen: Bladder neck tumour.

Macro: Pieces of firm tan tissue, together 28x20x8mms.

Immunohistochemistry:
None.

Female 39 years

Oncocytoma-right-sided upper pole lesion.



Specimen: Right Partial Nephrectomy.

Macro: Brown nodular tumour 26x26x30 mm.

Immunohistochemistry:
N/A.

Female 39 years

Solid lesion left side ?TCC ?adenoCa.



Specimen: Bladder tumour.

Macro: 8g of bladder tissue. All embedded.

Immunohistochemistry:
None performed.

Male 29 years

Kidney tumour, partial nephrectomy.



Specimen: H&E is of tumour and adjacent uninvolved kidney.

Macro: 3cm well circumscribed tumour with tan, variegated cut surface.

Immunohistochemistry:
Pan-cytokeratin (AE1/3) focally positive, Vimentin positive, CD10 focally positive, HMB45 negative, TFE3 (done elsewhere) positive. FISH analysis (done elsewhere): TFE3 gene rearrangement.

Male 71 years

Previous history of a G2 pTa urothelial carcinoma and previous carcinoma in situ both of which had been refractory to BCG therapy.



Specimen: Cystectomy.

Macro: None specified.

Immunohistochemistry:
N/A.

Female 71 years

Superficial tumour.



Specimen: TUR Bladder tumour.

Macro: About 0.5 grams of tissue fragments.

Immunohistochemistry:
None.

Male 49 years

Circumcision for scarring.



Specimen: Foreskin.

Macro: Multiple pieces of skin largest measuring 30x20x10mm. Two of these pieces show a firm white surface.

Immunohistochemistry:
Nil.

Male 64 years

Bladder tumour ? invasive TCC.



Specimen: TURBT.

Macro: 28g of friable tissue chippings.

Immunohistochemistry:
CK20, CEA and CDX2 positive. CK7, PSA and TTF1 negative.