Male 64 years

Upper pole mass ? RCC.



Specimen: Partial nephrectomy.

Macro: Within the kidney confined by the capsule was a tan coloured partly haemorrhagic mass measuring 35mm maximally.

Immunohistochemistry:
Positive membranous staining with CK7

Female 67 years

Periurethral round lesion excised transvaginally? cyst? tumour.



Specimen: Periurethral Lesion.

Macro: Firm round nodule 20x14x10mm. Slicing reveals greyish surface. No cyst.

Immunohistochemistry:
N/A

Male 35 years

Right testicular mass on ultrasound. Normal tumour markers.



Specimen: Testis Tumour.

Macro: Testis 62x38x20mm with cord 65mm in length and 10mm in diameter. Cut section shows a tumour in the lower pole of the testis measuring 16x15x13mm. The tumour appears confined to the testis with no extension into the rete or epididymis or spermatic cord.

Immunohistochemistry:
N/A

Male 68 years

7 cm mass. Right radical nephrectomy.



Specimen: Kidney.

Macro: Multiloculated cortical cystic lesion with some solid areas measuring 55x87x65 mm. No sinus fat/perinephric fat or vascular invasion seen.

Immunohistochemistry:
N/A

Female 72 years

New bladder tumour. Clinically invasive.



Specimen: Tissue chippings.

Macro: 18g of firm and friable tissue chippings.

Immunohistochemistry:
N/A

Male 79 years

Previous TCC. Also has metastatic melanoma (head and neck). Tumour around bladder neck and "pigmented" tumour left postero - lateral wall.



Specimen: Bladder biopsy.

Macro: Multiple fragments of brownish tissue aggregated at 25mm.

Immunohistochemistry:
Positive: Melan A and S100 Negative: Cam 5.2 and MNF 116

Male 47 years

TUR of recurrence of tumour dome. Ureteric bladder tumour.



Specimen: Urinary Bladder biopsy.

Macro: Three tan fragments the largest 10x5x3mm,the smallest 5x3x2 mm. [3(1); NR].

Immunohistochemistry:
N/A

Male 79 years

Right testicular mass with a history of tumour. ?tumour right inflammatory or haemorrhagic.



Specimen: Right testis.

Macro: Orchidectomy weighing 309g. Testis- 150x90x55mm, spermatic cord-130x20mm. Externally - smooth and lobulated. Cut surface- entire testis replaced by solid tan tumour showing areas of hemorrhage and necrosis. It involved the cord, epididymis and rete testis. No breach of tunica albuginea present.

Immunohistochemistry:
CD20, CD79a and Bcl-2 positive. Cyclin D1, CD23, CD10, Tdt, CD99, CD43, CD138, CD117 and EBV negative. Weak patchy nuclear positivity with BCl-6 and MUM-1. Ki-67 proliferation index - 95%

Male 71 years

Bulky bladder mass.



Specimen: Bladder.

Macro: bladder chippings.

Immunohistochemistry:
positive CD56,SYNAPTOPHYSIN and weak staining by chromogranin. CD 45 and MNF 116 are negative. Proliferation index with Ki67 is high

Male 64 years

Intrabdominal testis. Normal tumour markers.



Specimen: Testis.

Macro: Testis containing a pale solid tumour mass measuring 30x20mm.

Immunohistochemistry:
Positive staining with PLAP and CD117. Negative staining with Melan A and CD30.

Female 35 years

Left upper pole renal mass, sickle cell trait.



Specimen: Partial nephrectomy.

Macro: Partial nephrectomy of the upper pole measuring 50x35x30 mm. At the superior aspect of the specimen there is a partly cystic and partly solid lesion 30x16x20 mm within 2 mm of the surgical resection margin.

Immunohistochemistry:
MNF116+, CK7+, vimentin+, CD68-, CD10-, CEA-

Female 70 years

Right radical nephrectomy for renal tumour, with extension into inferior vena cava.



Specimen: Kidney: Radical nephrectomy. Slide of hilar lymph node.

Macro: The kidney showed confluent nodules of cream-coloured tumour, measuring 12cm in maximum diameter and showing macroscopic extension into hilar fat and present at renal vein resection margin. One involved hilar lymph node is also identified (the submitted slide).

Immunohistochemistry:
None

Male 59 years

Patient underwent radical prostatectomy following diagnosis of cancer on prostate needle biopsy.



Specimen: Scanned images only.

Macro: Educational case - none provided.

Immunohistochemistry:
HMCK and p63 stains were absent from all the large dilated PIN-like glands. Some of these glands extend out of the prostate adjacent to adipose tissue

Male 77 years

Patient with an elevated serum PSA level underwent a prostate needle biopsy.



Specimen: Scanned images only - needle biopsy.

Macro: Educational case - none provided.

Immunohistochemistry:
HMCK and p63 stains were present around all of the acini with atypical cells (not included)

Male 67 years

Patient found to have Gleason score 3+4=7 adenocarcinoma of the prostate on needle biopsy and underwent a radical prostatectomy. Gleason score 3+4=7 adenocarcinoma was present in the peripheral zone with focal extra-prostatic extention and a focally positive margin. In addition, a seperate histologicallydistinct large bilateral anterior tumour was noted and sent for consultation.



Specimen: scanned images only.

Macro: Educational case - none provided.

Immunohistochemistry:
None provided

Male 78 years

Patient with a history of T3 colon cancer underwent a prostate needle biopsy for elevated serum PSA levels.



Specimen: Scanned images only.

Macro: Educational case - none provided.

Immunohistochemistry:
Positive for synaptophysin

Male 65 years

Patient underwent radical prostatectomy following a diagnosis of cancer on prostate needle biopsy.



Specimen: Scanned images only.

Macro: Educational case - none provided.

Immunohistochemistry:
Nodule negative for basal cells (using 34BE12 antibody) and positive for alpha-methylacyl-CoA racemase.

Male 60 years

Patient underwent prostate needle biopsy due to an elevated serum specific antigen of 9.0ng/ml.



Specimen: Scanned images only.

Macro: Educational case - none provided.

Immunohistochemistry:
None