Male 64 years

Right renal hilar tumour in a solitary kidney.



Specimen: Right partial nephrectomy/enucleation specimen.

Macro: Partial nephrectomy specimen comprising a lobulated tumour with adjacent hilar fat. The tumour measures 45mm in maximum dimension and the cut surface has a diffuse mahogany brown appearance. It extends to the surgical margin in places. No background normal renal parenchyma is identified.

Immunohistochemistry:
Scattered cells positive for CK7. Stong and diffuse staining for CD117. Patchy staining for CD10. Negative staining for RCC antigen and vimentin.

Male 37 years

Cystic swelling of left testis Ultrasound: tumour invading testicular capsule.



Specimen: Left testicular mass.

Macro: Left testis 11.6 x 8 x 5.6cm with attached cord 5.2cm in length. 390g. Sectioning reveals a large heterogeneous tumour 8.5cm max with focal haemorrhagic and cystic areas. Grossly confined to the testis.

Immunohistochemistry:
AFP and Cam 5.2 positive. Oct 4, HCG and CD30 negative

Female 34 years

Solid Tumour, right bladder wall,negative urine cytology. A bit atypical at TURBT.



Specimen: Bladder chippings.

Macro: 7 grams of bladder chippings.

Immunohistochemistry:
N/A

Female 44 years

?left cystic renal cancer.



Specimen: Left Kidney.

Macro: Well defined cystic lesion involving the lower 2/3 of kidney, containing clear serous fluid, measuring 13 x 10 x 6 cm. No solid areas.

Immunohistochemistry:
N/A

Female 79 years

Left pyonephrosis 10 weeks. Unwell, weight loss.



Specimen: Radical Nephrectomy.

Macro: A kidney with attached perinephric tissue weighing 274g. The kidney measures 74x50x35mm with attached perinephric fat up to 30 mm. Adrenal gland is not identified. The ureter appears to be cut almost flush to the periureteric junction. On bisection, renal pelvis is dilated to 52mm maximum dimension. Renal calyces and adjacent cortex show multiple soft yellowish areas suggestive of suppuration measuring up to 18mm maximum dimension throughout. Renal pelvis is also markedly congested. Renal cortex is approximately 4mm thick.

Immunohistochemistry:
CD68 positive,pancytokeratin negative, EMA negative

Female 64 years

Right Nephroureterectomy for lower 1/3 ureteric tumour.



Specimen: Ureter Tumour.

Macro: Ureteric tumour-100mm length and 15mm width, lying 7mm above the distal ureteric resection margin.

Immunohistochemistry:
None

Male 81 years

Phimosis. Cauliflower growth on glans penis.



Specimen: Penile Biopsy.

Macro: Three irregular pieces of tissue, largest 8x7x2 mm.

Immunohistochemistry:
None

Male 29 years

Left testicular pain treated with antibiotic but was useless. USS suggest left testicular Ca.



Specimen: Left testis.

Macro: Left Testicle: The testis measures 60x46x30mm. The spermatic cord measures 75x15mm. On sectioning the parenchyma is entirely replaced by white with verigated colour tumour measuring 40x35x28mm.The tumour abuts the the tunica albuginia but does not appear to breach it. Macroscopically the tumour appears confined to the testis. The spermatic cord appears unremarkable. On further sectioning the tumour shows focal haemorrhage with possible areas of necrosis.

Immunohistochemistry:
None

Male 87 years

Hx of TCC bladder G2 and G3. Red patch anterior wall? CIS.



Specimen: Bladder biopsies.

Macro: Two fragments 6x5x3mm and 5x5x4mm, all taken.

Immunohistochemistry:
None

Male 74 years

Known prostate cancer treated with hormones. Persistently bleeding from bladder. Palliative cystectomy. Tumour grown rapidly over 6 months. Two previous TURPS.



Specimen: Cystectomy.

Macro: Large tumour filling bladder connected to bladder neck and prostate.

Immunohistochemistry:
Positive for vimentin, weak focal positive for MNF116 Negative for CK20, CK7, PSA, desmin, SMA

Male 71 years

Patient with muscle invasive bladder carcinoma and urothelial CIS on previous TURB. Note: High grade urothelial carcinoma (pT3a, N2) and CIS readily identified in other sections although superficial tumour only focally apparent in the submitted section for EQA.



Specimen: Radical cystoprostatectomy.

Macro: A radical cystoprostatectomy specimen in which the bladder mucosa appears diffusely erythematous and measures up to 15mm thick. No distinct tumour mass identified on gross examination.

Immunohistochemistry:
The spinle cell proliferation is positive for SMA, AE1/AE3 and vimentin. There is patchy staining for caldesmon, patchy weak staining for Alk 1 and negative staining for EMA

Female 79 years

Right Nephrectomy.



Specimen: Kidney Tumour.

Macro: 38mm tumour in upper pole of right kidney. The tumour had a yellow and dark haemorrhogic appearance. No evidence of perinephric or renal sinus invasion.

Immunohistochemistry:
N/A