Female 63 years

Upper urinary tract obstruction. Nodule seen on cytoscopy. Previous history of breast carcinoma. Immunohistochemistry: CK7 positive, ER positive.



Specimen: Bladder biopsy.

Macro: Two greyish tissue pieces aggregating 7mm.

Male 59 years

Left RCC.

Immunohistochemistry:
CK7, EMA, Vimentin, AMACR- Positive. 34BE12- Focal Positive. E-Cadherin - Negative.



Specimen: Nephrectomy for tumour.

Macro: Tumour at upper pole 86x80x65mm with a variegated yellow and haemorrhagic appearence on cut surface.

Male 41 years

Hard mass upper pole left testis.

Immunohistochemistry:
Thyroglobulin and TTF-1 Negative, Cytokeratin positive cells lining cystic areas. Remaining tumour vimentin positive and inhibin positive.



Specimen: Testis.

Macro: Cut section showed firm yellow area with gelatinous foci 30mm in diameter.

Female 85 years

Left renal RCC, left Kidney.



Specimen: Left kidney.

Macro: Kidney measuring 9.8x5.5x4.0cm with a brown tumour 3.2cm diameter in the midzone. Tumour is dark brown with an area of scarring/calcification.

Male 82 years

Extensive bladder tumour? Extending into prostate.

Immunohistochemistry:
CK5 positive.



Specimen: TURBT.

Macro: 11grams of bladder chippings.

Male 65 years

Carcinoma of prostate, DXT, PSA0.2. Mass on CT causing hydronephrosis. TUR probably prostate.

Immunohistochemistry:
PSA PSAP negative, TTF-1, CD56, synaptophysin chromogranin and CAM 5.2 positive.



Specimen: Bladder biopsy.

Macro: 2g of curettings.

Male 47 years

Excision of lesion urethral meatus.

Immunohistochemistry:
HMB-45 strongly positive, NKI/C3 & S100 focally positive, Melan A focally strong positive.



Specimen: Biopsy from urethra (meatus).

Macro: Darkly pigmented nodule of skin measuring 8x7x4mm.

Male 91 years

Patient had mucosa prostate urethra ?TCC, ?Inflammatory, stricture urethra.



Specimen: Prostatic biopsy.

Macro: None given.

Male 42 years

Bilateral testicular tumours.



Specimen: Right orchidectomy.

Macro: 32mm tumour.

Male 31 years

Enlarged and hard left testis.

Immunohistochemistry:
tumour is alpha FP and CD30 focally positive.



Specimen: Left testis.

Macro: Majority of testis replaced by tumour measuring 85x45mm. Cystic and haemorrhagic areas noted.

Male 70 years

Right kidney space occupying lesion.

Immunohistochemistry:
tumour cells strongly positive CD10, cytokeratin (Cam 5.2), CK7, CK19 (patchy) and vimentin (patchy). High mol weight CK (34BE12) is negative.



Specimen: Nephron sparing surgical excision of renal tumour.

Macro: Renal parenchyma measuring 40x30x15mm bearing a nodular tumour mass measuring 50x45x30mm with attached fibrofatty tissue measuring 90x30x10mm free of tumour. Weighs 92 grams. On slicing the tumour has pale yellow brown friable cut surface with areas of necrosis and haemorrhage. The capsule overlying the tumour is thin but appears intact. The nearest renal parencymal margin is 5mm from the tumour.

Male 66 years

FOR EDUCATION AND INTEREST ONLY. Biopsy of bladder base, and red area ?CIS. H/o Gleason 4+5. Metastic prostate ca, ESRF on dialysis.

Immunohistochemistry:
strongly positive - PSA, AMACR and CD57. Negative - thrombomodulin, P63, 34BE12,CK5/6, CK7 and CK20.



Specimen: TURBT.

Macro: Multiple pieces of pale tan and white tissue, together measuring 2.5x2.0x0. 4cm. Some of the pieces appear to be quite fragile. All embedded.