Female 25 years

Left radical nephrectomy for renal tumour.



Specimen: Radical nephrectomy.

Macro: A radical nephrectomy containing a tumour in the kidney measuring 115 mm in maximum dimension, with a pale rubbery cut surface and a lobulated appearance with yellow, gelatinous and haemorrhagic areas. It is located mid-kidney and in the lower pole.

Immunohistochemistry:
Epithelioid areas with tubules and sheeted compact (non-spindle cell) areas diffusely positive for PAX8, AE1/3, WT1 and CD56. MIB-1 >70%. Negative for chromogranin, synaptophysin, MIC-2 (CD99), desmin and myogenin.

Male 44 years

Right testicular lump Elevated AFP, LDH, HCG.



Specimen: Right orchidectomy.

Macro: Right testis measuring 80 x 45 x 50mm. Spermatic cord 30mm length. Weight 115g. The testis contains a 50 x 40 x 40mm firm grey tumour, which has a partly lobulated and cystic appearance. Tumour appears clear of the epididymis. There is a fine rim of normal testicular tissue surrounding the tumour, and the rete testis is difficult to identify.

Immunohistochemistry:
Provided. AFP, HCG, MNF116, CD30 & OCT3/4.

Male 31 years

Left radical inguinal orchidectomy for testicular cancer.



Specimen: Left testicle.

Macro: A testis measuring 75x45x35mm with attached spermatic cord measuring 40mm in length and up to 7mm in diameter. The external surface of the specimen appears smooth and intact. On slicing, almost the entire testicular parenchyma is replaced by a multinodular solid yellow-white tumour measuring 60x42x35mm. Macroscopically the tumour does not involve the epididymis or the tunica vaginalis.

Immunohistochemistry:
None undertaken.

Female 76 years

Lesion in dome of bladder.



Specimen: Partial cystectomy.

Macro: Polypoid lesion measuring 25x23x15mm with underlying bladder and fat measuring 100x60x15mm. There is a thin cuff of bladder mucosa around the lesion.

Immunohistochemistry:
None.

Female 73 years

Non-functioning kidney.



Specimen: Left nephrectomy.

Macro: Kidney with attached perinephric fat. The whole specimen measures 170mm from pole to pole. Vascular clips are present at the presumed hilum. On slicing the kidney measures 135mm from pole to pole. There is extensive dilatation of the whole of the pelvicalyceal system and the calyces are filled with yellow/green pus. There is severe cortical atrophy associated with extensive fibrosis and areas of necrosis. Some of the necrotic areas extend into perinephric fat. No mass lesions are identified.

Immunohistochemistry:
None.

Female 71 years

Right partial nephrectomy.



Specimen: Right partial nephrectomy.

Macro: Partial nephrectomy with a well circumscribed tan brown lesion, 24mm in size, abutting the capsule and clear of margins.

Immunohistochemistry:
Negative: CK7, Melan A, CAIX, MNF116, Pax8, HMB45, CD117 (stains numerous mast cells also Toluidine blue positive), Stat6, EMA, Bcl2 (some background cytoplasmic staining but no nuclear positivity in tumour cells). CD99 focally positive. Provided: Macro image, CD34, SMA and electron microscopy of the tumour.

Male 32 years

Right testicular tumour. Tumour markers negative.



Specimen: Right orchidectomy.

Macro: Right orchidectomy showing an area of poorly defined yellow/grey discolouration of the testicular parenchyma, measuring 25mm in maximum dimension.

Immunohistochemistry:
N/A.

Male 64 years

TURP for retention. ?Malignant. Diabetic. Has no previous urological history.



Specimen: TURP.

Macro: 24g of prostate chips. Representative block.

Immunohistochemistry:
Microbial stains negative.

Female 74 years

Nephro-uretrectomy for Ureteric tumour.



Specimen: Ureter.

Macro: Distal ureteric tumour with proximal hydroureter.

Immunohistochemistry:
None.

Female 55 years

Large tumour invasive right wall.



Specimen: TURBT.

Macro: Chips filling 16 cassettes all taken.

Immunohistochemistry:
Tumour positive for MNF116, GATA3, CK7, p63 and CK20. Negative for PAX8, vimentin, racemase, inhibin, CA125, CEA.

Female 85 years

Suspicious growth throughout bladder Not typical of TCC.



Specimen: TURBT.

Macro: Pot labelled - Bladder tumour 4 grams of chippings. All embedded.

Immunohistochemistry:
N/A.

Female 40 years

Tuberous sclerosis complex, 43mm left renal lesion was diagnosed radiologically as an AML 2013 -. As growing MDT discussion for biopsy as radiological findings non-conclusive for diagnosis.



Specimen: Kidney biopsy.

Macro: Single core 11mm plus fragments.

Immunohistochemistry:
Ck7, CD117, Vimentin - provided. PAX8 positive. Cathepsin K negative.

Male 65 years

PSA 3000.



Specimen: Prostate needle biopsy.

Macro: 2 cores.

Immunohistochemistry:
None.

Male 73 years

PSA 2.18, Volume 69cc MRI - 14mm PIRADS-4 lesion left apex transition zone posterior part T2a N0 M0.



Specimen: TRUS biopsy (Left lateral Base).

Macro: One thin cream needle core biopsy measuring up to 16mm.

Immunohistochemistry:
34BetaE12 & P504S.

Male 62 years

PSA 8.76. MRI shows Likert 3/5.



Specimen: Prostate core biopsy.

Macro: Two cores measuring 13mm and 12mm.

Immunohistochemistry:
None.