Male 68 years

?RCC left kidney.



Specimen: Left radical nephrectomy.

Macro: 73mm well circumscribed tumour in lower pole. Solid grey cut surface.

Immunohistochemistry:
None.

Male 78 years

Bladder tumour. History of TCC.



Specimen: Bladder biopsy.

Macro: Multiple fragments of tissue 1 gram in total.

Immunohistochemistry:
AE1/3, CK7 and 34BE12/p63 cocktail stain large cells. Large cells are CD45 negative.

Female 55 years

Left nephrectomy specimen. ? RCC.



Specimen: Left Nephrectomy.

Macro: A nephrectomy specimen measuring up to 150 mm superoinferiorly, 90 mm transversely and 80 mm AP. Involving most of the upper pole and in the mid part of the kidney there is a large focally cystic renal tumour measuring up to 100 x 75 mm. The tumour appears to extend to the capsule. There is focal representation of white material in the perinephric fat at the superior pole which may represent tumour.

Immunohistochemistry:
N/A.

Male 47 years

From request form - Previous vasectomy many years ago. Now right hemiscrotal lump.



Specimen: Paratesticular mass.

Macro: A solid, cream coloured smooth surfaced nodule measuring 22 x 24 x up to 18mm. Slicing reveals a solid cream and yellow coloured cut surface.

Immunohistochemistry:
Calretenin and cytokeratin: positive CEA: negative.

Female 62 years

Bladder mass biopsied.



Specimen: Bladder biopsy.

Macro: Two biopsies 5-6mm.

Immunohistochemistry:
N/A.

Male 40 years

Suspected testicular cancer. Orchidectomy.



Specimen: Orchidectomy.

Macro: Testis with attached spermatic cord. Testis contains a nodular, solid white tumour measuring 43 x 35 by 35mm is which is confined within the testis.

Immunohistochemistry:
None.

Male 58 years

Large pedunculated bladder tumour arising from interureteric bar.



Specimen: TUR bladder.

Macro: 25g tissue chippings. Slide submitted to EQA representative of whole lesion, processed in its entirety.

Immunohistochemistry:
None undertaken.

Female 54 years

No clinical information provided.



Specimen: Right partial nephrectomy.

Macro: Partial nephrectomy 31x21x25mm including a well circumscribed tan tumour 20mm in diameter.

Immunohistochemistry:
Positive: CAM5.2, Pax-8, CD10 (patchy). Negative: MNF116, CK7, vimentin, AMACR, WT1, CD99, Melan-A.

Male 53 years

Admitted for left orchidectomy for testicular cancer. Noticed a lump in his left testicle associated with pain. Markers (AFP, HCG, LDH) all normal.



Specimen: Left testicular tumour.

Macro: Received a left testis weighing 33grams and measuring 50 x 38 x 27mm with 68mm of cord. On sectioning there is a tan coloured nodule in the upper pole of the testis measuring 16 x 12 x 11mm. This has a circumscribed encapsulated appearance.

Immunohistochemistry:
On IHC staining the tumour cells are strongly positive for inhibin, calretinin, Melan-A and vimentin. The germ cell tumour OCT3/4 is negative. S100 and the epithelial marker CAM 5.2 are negative. Ki-67 staining is very low < 1%.

Female 69 years

?RCC.



Specimen: Partial nephrectomy.

Macro: Left partial nephrectomy measuring 70x40x30mm. The surgical margin is painted green. Cut surface reveals a circumscribed whitish nodule measuring 39x25x55mm which is clear of the margin by about 15mm.

Immunohistochemistry:
The tumour cells express diffuse positivity for desmin, actin, focal positivity for HMB45 and are negative for AE1/AE3, PAX8, CK7 and AMACR.

Female 43 years

Large bladder tumour 4-5cm left lateral wall.



Specimen: TURBT.

Macro: Multiple fragments together 80mm.

Immunohistochemistry:
ALK, p63, ki67 - submitted. Positive for SMA and focally positive for Desmin. Negative for MNF116 and h-caldesmon.

Female 57 years

Left renal Bosniak III cyst.



Specimen: Radical Nephrectomy.

Macro: The specimen consists of a kidney with perinephric fat together measuring 120 x 65 x 60mm. On slicing there is a multiloculated cystic tumour present measuring a maximum of 55 x 45 x 40mm. This is within the kidney parenchyma and has a pushing margin with the renal sinus. There is no macroscopic direct invasion into the renal sinus fat or the perinephric fat. The tumour distends the renal capsule but does not appear to breach it. It is 30mm from the vascular resection margin.

Immunohistochemistry:
Tumour positive for CK8/18, vimentin,CD10, and AMACR. Occasional of the epithelial cells are CK7 positive (this also highlights entrapped tubules within the tumour). The epithelial cells lining the cysts are negative for 34 beta E12, CD117, CaIX, HMB 45, melan A, ER, PR (the stroma is also negative for HMB45 and melan A, and for CD10, ER, PR). The SDHB and fumarate hydratase immunohistochemistry is positive (there is no evidence of succinate dehydrogenase deficiency or of fumarate hydratase deficiency).

Male 74 years

PSA 40.



Specimen: Prostate Needle biopsy.

Macro: 2 cores.

Immunohistochemistry:
None.

Male 58 years

PSA 7.2, tender DRE, MRI 2/5, transperineal prostate biopsies.



Specimen: Prostate core biopsies.

Macro: Two cores plus fragments measuring 5 and 12mm in maximum length.

Immunohistochemistry:
None.

Male 75 years

PSA 8.78UGL. LEFT PZ TARGET. RIGHT PZ SAMPLE.



Specimen: RIGHT PZ SAMPLE.

Macro: Five pale cores measuring 4, 10, 10, 20 & 22mm. B1 (3); B2 (2) AT. (B2 provided).

Immunohistochemistry:
None.