Male 77 years

Excisional biospy of skin lesion on the back. >2 year history of progressive scarring. ?Fibrosis to back. ?Dermatofibroma.

Macroscopic description:
An ellipse of skin with some subcutaneous tissue measuring 60x30x20mm. There is a depressed scar on the surface with a diameter of 20mm. Serial slicing reveals diffuse fibrosis of the dermis and subcutaneous tissue.

Male 7 years

Incisional skin biopsy. Undergoing chemotherapy for haematological malignancy. New "skin lesion" developed on left upper anterior chest wall.

Macroscopic description:
A skin ellipse measuring 18x5x10mm. Cream coloured dermal nodule noted on section.

Immunohistochemistry:
Cells forming the infiltrate stain positively with antibodies to CD4, CD33, CD43, CD68 (focal), CD117, CD123 and myeloperoxidase. Negative for CD3, CD7, CD10, CD20, CD34, CD56, CD61, CD79a, CD303 (BDCA2), TdT and glycophorin A.

Female 67 years

Skin punch biopsy right cheek. Right cheek - firm purple plaque ?sarcoidosis ?cutaneous lymphoma. New lesion appearing on central cheek.

Macroscopic description:
3mm punch biopsy with a depth of 5mm.

Female 53 years

Skin from flank. Erythematous scaly patches, 20 year history, left flank biopsy.

Macroscopic description:
Incisional biopsy of skin measuring 10x4x10mm. Positive for CD2, CD3, loss of CD5, loss of CD7, CD4, and CD8 postive. CD30 is negative, few CD20 positive B cells.

Female 14 years

Skin. Swelling left side of nose present approximately for 9months.

Macroscopic description:
Disc of nodular skin 9mm in maximum extension.

Male 43 years

Incisional skin biopsy. History of Sjorgren's. Previous NHL. Skin lesion on scalp ?aetiology.

Immunohistochemistry:
Tumour cells diffusely positive for CD31 and patchily positive for SMA. Negative for HHV8.

Female 50 years

Diagnostic biopsy left hip. Rash affecting arms, lower legs and hips. Widespread plaques with papular periphery.

Macroscopic description:
An ellipse of skin, 10x5x7mm.

Female 38 years

4mm punch biopsy from skin of abdomen. 34 weeks pregnant in 3rd pregnancy. History of possible pemphigoid gestationis in first pregnancy. Presents with erythematous eruption umbilical and periumbilical area but no blisters at time of biopsy. Skin subsequently blistered over the following week.

Immunohistochemistry:
direct immunofluorescence of perilesional skin showed linear C3 deposititon along the basement membrane and no staining for IgG, IgA, IgM or fibrinogen. Indirect immunofluorescence on monkey oesophagus showed no staining.

Female 83 years

Lump right thigh. Tissue fragments 2.2x0.5cm, no overlying skin received.

Female 22 years

Incisional biopsy. Suspected pityriasis rubra pilaris. Differential diagnosis psoriasis.

Macroscopic description:
Wedge biopsy of skin. 1.2x0.5x0.4cm bisected longitudinally and all embedded.