Female 60 years

Vulval biopsy. Thickened left labia. H/o travel abroad.

Macroscopic description:
A cream coloured piece of tissue measuring 4mm in maximum dimension.

Male 45 years

Skin, excision biopsy. Very vascular tumour right thigh 2-3months ?Angiokeratoma. ?MM.

Macroscopic description:
an ellipse of skin measuring 22x10x up to 9mm; bearing a 7x6x2mm centrally raised grey papule with an indurated surface. The lesion extends to 2mm from the nearest margin. The lesion is submitted in blocks A&B (not all embedded).

Immunohistochemistry:
The lesional cells are negative for CD34, CD31, melan-A, actin, desmin and S100.

Female 88 years

Incisional biopsy right cheek. Longstanding lesion right face. Growing in size recent past (over few weeks). Spreading through right face.

Macroscopic description:
A skin ellipse 9x3mm to a depth of 9mm. Skin surface unremarkable.

Immunohistochemistry:
CD20, Bcl 2, Bcl 6 and MUM1 strongly and diffusely positive. Ki67 brisk. Occasional cells positive with Cyclin D1 and CD30. Negative for CD3, CD5, CD21, CD23 and EBER-ISH.

Male 50 years

Incisional biopsy. History of crusted blistering lesions. New lesion chest now. Very ulcerated mouth and genitals.

Macroscopic description:
Tan biopsy of the skin 4x4x5mm.

Immunohistochemistry:
Immunoflourescence showed strong intercellular IgG and moderate intercellular C3 in the epidermis. IgM and IgA were both negative.

Female 88 years

Skin ellipse excision, scalp. Skin tumour scalp. No other history available.

Macroscopic description:
Skin ellipse 40x29x8mm. A friable tan warty nodule 28mm.

Immunohistochemistry:
Positive - CK8/18, BerEP4, CD56. Focal positive: EMA. Rare cells positive: 34βE12. Negative: CK7, CK20, TTF-1, chromogranin A, synaptophysin, CEA, p63, CK5/6. ABPASD: no mucin.

Male 3 years

6mm punch biopsy - back. Blistering rash with epidermal detachment - TEN ? Drug ? Infection. Started off looking like an exanthem.

Immunohistochemistry:
IgG, IgG4, IgA, IgM, C3 and fibrin are negative.

Female 70 years

Punch biopsy. Vulval itch and redness. (Past history in 2013 - TCC bladder, cystectomy with removal of uterus, cervix and anterior vagina.)

Macroscopic description:
Punch biopsy: 4mm diameter and 6mm depth. Papillomatous areas along one edge.

Immunohistochemistry:
CK7, CK20, p63 - positive. CDX2 moderately positive. ER, MelanA, S100 - negative.

Female 53 years

Skin incisional biopsy. Persistent scaly plaque. Known lupus on hydroxychloroquine. DD lupus or ?SCC/Bowens.

Macroscopic description:
Specimen pot labelled - biopsy scalp. Received is a skin lesion measuring 10x5x5mm. There is a central keratotic nodule measuring 3mm in maximum dimension x 2mm in height. No tissue remains.

Male 43 years

Excision biopsy. Left right upper lip.

Macroscopic description:
Ellipse of skin measuring 18mmx10mmx9mm in depth, bearing a raised pale lesion 6mm in diameter and underlying firm pale nodule.

Female 53 years

Ellipse excision. Brown - red nodular plaque on the left cheek, present for several months.

Macroscopic description:
20x16x4mm irregular ellipse of skin, ill-defined surface roughening.