Sex unknown age unknown

Lump right side of nose for at least 10 years.

Specimen: Skin.

Macroscopic description:
Skin shave 7x5mm.

Female 29 years

28 weeks pregnant. Pruritic papules on abdomen and legs with vesicles in ring-like distribution around two of the lesions.

Specimen: Skin biopsy right wrist.

Macroscopic description:
Ellipse of skin 6x5x2mm.

Immunohistochemistry:
Direct immunofluorescence shows linear C3 along basement membrane.

Male 67 years

?Ganglion.

Specimen: Lump right foot.

Macroscopic description:
A firm pale mass measuring 5mm across.

Female 45 years

Lesion skin of right knee.

Specimen: Punch biopsy.

Macroscopic description:
A 4mm diameter punch biopsy 3mm in depth with a pale surface.

Female 41 years

Tender red nodule in left iliac fossa.

Specimen: Incisional skin biopsy, lesion left iliac fossa.

Macroscopic description:
An ellipse of skin measuring 20x10x8mm. Bisected longitudinally.

Immunohistochemistry:
The tumour cells express CD4, CD7, CD30, Perforin and ALK1 (nuclear and cytoplasmic). They are negative for CD2, CD3, CD5, CD8, CD56 and CD57. Staining for Epstein-Barr virus (LMP1, EBER) is negative. CT Chest/abdomen/pelvis revealed generalised lymphadenopathy.

Female 32 years

Excision of lesion right leg.

Specimen: Skin excision biopsy.

Macroscopic description:
An ellipse of skin, 40x23x13mm, bearing a red/brown nodule measuring 13mm.

Female 42 years

Erythematous nodular eruption anterior right lower leg ?erythema nodosum ?cellulitis ?panniculitis. No fungal hyphae, acid fast bacilli on special stains.

Specimen: Skin excision.

Macroscopic description:
Skin ellipse 10x3x8mm.

Male 38 years

Widespread erythema and blisters 2 days after starting penicillin for sore throat. ?drug reaction, ?staphylococcal scalded skin syndrome.

Specimen: Skin punch right chest.

Macroscopic description:
Punch biopsy of skin 4x4mm and 5mm deep.

Immunohistochemistry:
Blood cultures negative. No streptococcal infection isolated.

Male 40 years

Nodule at the tip of finger.

Specimen: Skin excision.

Macroscopic description:
None given.

Male 12 years

Lightly pigmented plaque left ear. No recent change.

Specimen: Excision lesion left ear.

Macroscopic description:
Skin 22x1724mm with 10mm light tan plaque, together with rim of cartilage peripherally. 3TS.

Female 31 years

A scaly arcoid erythema present for 2 months, trunk and limbs. ?Psoriasis. ?SCLE. Immunoflourescence studies show no significant immunoreactant deposition.

Specimen: Left thigh 4mm punch biopsy for histology and immunoflourescence

Female 51 years

Episodes of erosive/blister like lesions on trunk, neck, legs, hands. Five month history. Transient lesions which last about 1 month, come and go leaving a slight scar. ?Sweet's syndrome. Differential diagnosis erythema multiforme.

Specimen: Left abdomen 4mm punch biopsy.

Immunohistochemistry:
epidermal lymphocytes positive for CD3, CD8, CD56. They are negative for CD5 and BF1. Scattered CD30 positive cells in dermis

Male 56 years

Differential diagnosis: ?Panniculitis. Sent for culture. ?Sarcoidosis. Three week history of multiple pink/purple nodular subcutaneous lesions appearing on arms and legs, approximately six to eight in number and measuring 0.5cm to 1cm in maximum diameter. Some showing resolution after developing a punctum and discharging white pus like exudates. Some static, although now dusky purple colour and have become fluctulant as they were at onset. Past medical history: Known glioblastoma - surgery feb 2012. Temozolomide and radiotherapy in April and May 2012. Persistent extention of T.E. Cranial bone flap infection. Peroneal ulcer and paracolic abscess drained. Cultured - VRE anaerobes and yeast. Drugs: Tinzaparin, Sodium Valproate, Paracetamol, Vancomysin, Clobazam, Dexomethasone, Lamotrigine and Omeprazol.

Specimen: Left lateral thigh Incisional biopsy

Female 39 years

Very odd severe PV ulceration/vegetative lesion in groin.

Specimen: Left groin Incisional skin biopsy

Male 86 years

Purple red infiltrative plaque present for 1-4months. ?malignant, ?Sweets, ?Wells, ?CTCL.

Specimen: Right outer thigh 6mm Punch biopsy

Female 72 years

?Necrolytic migratory erythema. ?Zinc insufficiency. ?Pemphigus.

Specimen: Chest Incisional biopsy

Male 59 years

Vasculitic rash ovwer lower legs for greater than 12 months. On Dapsone and Prednisolone.

Specimen: Lower legs 5mm punch biopsy of skin

Female 67 years

Natal cleft affected area. ?Paraneoplastic pemphigus. ?Pemphigus.

Specimen: Natal cleft 4mm punch biopsy of skin