Female 65 years

Large erythematous plaques arms and thighs ? granuloma annulare.

Specimen: Skin incisional biopsy.

Macroscopic description:
Ellipse of skin 14 x 6 x 3mm, surface slightly raised towards one edge. Bisected.

Immunohistochemistry:
No immuno-histochemistry but alcian blue staining shows slight increase in dermal mucin.

Female 50 years

Red lunula and transverse overcurvature. ?Glomus ?myxoid cyst ???melanoma.

Specimen: Skin excision, nail matrix, right ring finger.

Macroscopic description:
A fragment of grey fleshy tissue measuring 7 x 5 x 3mm. Bisected to reveal a firm grey cut surface.

Immunohistochemistry:
Immunohistochemistry for SMA and h-caldesmon is positive in the lesional cells.

Female 61 years

Recurrent trichilemmal cyst from scalp.

Specimen: Excision from scalp.

Macroscopic description:
An ovoid piece of skin measuring 23 x 22 x 10 mm. On slicing there is a ?Cyst measuring 21 mm in maximum dimension with a firm cream/brown cut surface.

Immunohistochemistry:
N/A.

Male 56 years

Skin lesion, unsure if changing but two colours and not well demarcated ?atypical naevus ?melanoma.

Specimen: Excision skin lesion right thigh.

Macroscopic description:
Skin ellipse 17x6x4mm bearing a grey brown papule 2x1mm.

Immunohistochemistry:
IHC slides included.

Male 33 years

Grouped vesicular eruption over body and face - fewer present on lower limbs, no mucosal involvement ?HSV driven. Patient immunosuppressed.

Specimen: Right upper back, punch biopsy.

Macroscopic description:
4mm punch biopsy, embedded whole.

Immunohistochemistry:
N/A.

Male 71 years

Recently changed colour - for reassurance.

Specimen: Skin papilloma midline lower back.

Macroscopic description:
A piece of skin 17mmx 13mm x4mm.

Immunohistochemistry:
No.

Male 52 years

? Hailey Hailey disease.

Specimen: Punch biopsy left axilla.

Macroscopic description:
4 mm punch biopsy left axilla: Punch biopsy 0.4 cm.

Immunohistochemistry:
No.

Female 32 years

5 x 5 mm pigmented lesion right posterior forearm. Excision with 2 mm margins.

Specimen: Excision right posterior forearm.

Macroscopic description:
A skin ellipse measuring 10 x 8 x 4 mm in depth. Centrally there is a pigmented lesion that measures 4 mm in maximum diameter and is 2 mm from the nearest margin. The excision margins are inked green. Serially sliced and all embedded.

Immunohistochemistry:
None.

Male 54 years

Multiple lesions left calf and foot, Type V skin, HIV negative.

Specimen: Multiple lesion left calf and foot.

Macroscopic description:
n/a.

Immunohistochemistry:
n/a.

Male 51 years

Presents with erythematous patches with peripheral scaling and large scar skin changes in middle (involves face, neck and arm) previous biopsy discussed in combined clinic and recommended for repeat biopsy with IMF =? differentials Discoid lupus ? Morphoea (current biopsies taken form inflamed /erythematous areas of the rash / lesion).

Specimen: Incisional biopsy left preauricular cheek.

Macroscopic description:
Incisional biopsy left preauricular cheek: skin ellipse 1.2 x 0.5 x 0.3cm. Bisected longitudinally. EG/CF.

Immunohistochemistry:
IMMUNOFLUORESCENCE: C3: Diffuse granular deposition at the basement membrane zone. IgG: Weak diffuse granular deposition at the basement membrane zone. IgA: Diffuse granular deposition at the basement membrane zone. IgM: Diffuse granular deposition at the basement membrane zone.