Female 36 years

Long history of discoid lupus, now erythematous plaques on chest and face.

Specimen: skin punch biopsy, upper back.

Macroscopic description:
4mm punch biopsy.

Immunohistochemistry:
n/a.

Male 85 years

Exophytic lesion. Excision biopsy.

Specimen: Skin lesion right posterior shoulder.

Macroscopic description:
Skin ellipse with a central broad based pedunculated nodular lesion 4cm in diameter and grossly clear of excision margins.

Immunohistochemistry:
na.

Male 18 years

Congenital warty lesion, recent growth and bleeding.

Specimen: skin excision, back.

Macroscopic description:
Non-pigmented skin measuring 23x24x5mm with an irregular keratotic lesion measuring 20x18mm on the surface, 2mm from the closest resection margin.

Immunohistochemistry:
na.

Female 35 years

10 month history of raised plaque on both shins. Schizophrenia-on Clozapine. Diabetes - on Insulin and Metformin.

Specimen: punch biopsy right shin.

Macroscopic description:
6mm punch biopsy, bisected.

Immunohistochemistry:
na.

Male 42 years

Firm well delineated mass on the left hand.

Specimen: skin excision left hand.

Macroscopic description:
na.

Immunohistochemistry:
Positive for AE1/3, CK7, MNF116, S100, Desmin. Negative for EMA, CK20, Melan A, CD34.

Female 85 years

12x10mm pedunculated mass with crust, right lower back ?pyogenic granuloma.

Specimen: skin lesion lower back.

Macroscopic description:
14x9x8mm.

Immunohistochemistry:
na.

Female 45 years

Soft polypoid tissue excised from left buttock ?fibroepithelial polyp.

Specimen: skin left buttock.

Macroscopic description:
shave of skin 10x8x3mm showing a lesion 4mm in diameter.

Immunohistochemistry:
BRAF V600E positive, BAP1 negative in Spitzoid component.

Female 36 years

Chronic leg ulcers with eschars and necrotic fat some granulation. Two month history. Normal renal function. Alcoholic cirrhosis ?vasculitis ?cause.

Specimen: skin biopsy right upper thigh.

Macroscopic description:
Multiple pieces of irregular firm ?necrotic tissue, largest 125x80x12mm, smallest 23x20x2mm.

Immunohistochemistry:
na.

Female 52 years

Burning and itching wheals with petechiae on trunk and upper arms.

Specimen: biopsy from rash on left upper arm.

Macroscopic description:
ellipse of skin measuring 7x7x15mm.

Immunohistochemistry:
IMF negative.

Female 47 years

Papillomatous lesion on left cheek. Clinical differential: Basal cell carcinoma? Adnexal tumour?

Specimen: excision of lesion on left cheek.

Macroscopic description:
A pale ellipse of skin 17x8x3mm in depth with a pale domed central lesion 8x5x7mm in height.

Immunohistochemistry:
na.

Male 40 years

Eczematous rash on forearams, neck and chest whilst on sunny holiday ? photoallergic dermatitis ?lupus.

Specimen: Digital only case - Punch Bx from forearm.

Macroscopic description:
Punch biopsy.

Immunohistochemistry:
N/a.

Female 17 years

Raised lesion left knee, shave excision.

Specimen: Digital only case - shave excision left knee 1 H&E and 4 immunos provided.

Macroscopic description:
Nodular piece of tissue 12x8x4mm.

Immunohistochemistry:
S100, CD31, Factor X111 and AlkD5F3 provided. Other immunos: negative for Alk1, Cytokeratins, SMA, Desmin, CD34, ERG and Melan A.