Male 57 years

15mm lesion occiput.

Specimen: Occipital biopsy.

Macroscopic description:
Two pieces of tissue 20x5x5mm.

Immunohistochemistry:
none.

Male 59 years

?Malignant change.

Specimen: Foreskin.

Macroscopic description:
75x23mm with a plaque like area - 40x23mm.

Immunohistochemistry:
n/a.

Female 64 years

Lesion has become larger the last 6months.

Specimen: Excision of skin from face.

Macroscopic description:
A nodule of pale wrinkled skin measuring 10x10x10mm.

Immunohistochemistry:
S100 and SOX10 positive. Melan-A shows patchy positivity. FXIIIA, HMB45, CD34, desmin, MITF, tyrosinase - negative.

Female 24 years

?BCC ?adnexal.

Specimen: Punch biopsy left cheek.

Macroscopic description:
n/a.

Immunohistochemistry:
n/a.

Male 25 years

Left anterior chest wall lump.

Specimen: Excision left anterior chest wall.

Macroscopic description:
A piece of fibro fatty tissue measuring 14x9x5mm with attached firm nodule measuring 8x5x4mm. Slicing the nodule reveals a homogenous grey-white surface. The specimen is inked blue.

Immunohistochemistry:
n/a.

Female 24 years

New mole increased size ?Naevus ?Vascular ?MM.

Specimen: Punch biopsy right mid back.

Macroscopic description:
Punch biopsy 8x6mm bearing a central warty lesion 5x4x2mm. Bisected.

Immunohistochemistry:
S100 and Melan A positive. HMB45 patchy positive (mostly superficial).

Female 54 years

5/12 history of lesion anterior right thigh. ?dermatofibroma ? Amelanotic Malignant Melanoma.

Specimen: Excision biopsy.

Macroscopic description:
EOS 15x7x6mm bearing a central well circumscribed, slightly raised cream nodule 5mm in diameter.

Immunohistochemistry:
none.

Female 85 years

Rapid growing lesion on cheek. ?Squamous cell carcinoma.

Specimen: Skin biopsy right cheek.

Macroscopic description:
Ellipse 40x30mm bearing a fungating lesion 35mm x35mm.

Immunohistochemistry:
Chromogranin +ve, synaptophysin +ve, CD117 +ve, CD56+ve, Cam5.2 +ve, BerEP4 +ve, CK20 +ve, TTF1 - negative, Ki67>90%.

Male 86 years

Multiple skin lesions. HIV negative.

Specimen: Skin right index finger.

Macroscopic description:
7mm punch biopsy.

Specimen: CD34 and HHV8 positive.

Female 20 years

3 year history - recurrent erythematous nodules on outer aspects of thighs, only present in winter months.

Specimen: Left lateral thigh - punch biopsy.

Macroscopic description:
4mm diameter, 6mm deep, darkened surface.

Immunohistochemistry:
none.

Female 38 years

?melanoma.

Specimen: Excision biopsy left upper arm.

Macroscopic description:
Skin ellipse with a darkly pigmented asymmetric lesion measuring 4x3mm.

Immunohistochemistry:
AD11 (a) H&E (slide 509348), AD11 (b) Beta catenin (slide 509363).

Female 47 years

Brownish macular lesions lower trunk and legs.

Specimen: Punch biopsy abdomen.

Macroscopic description:
Punch bx 5mm wide and 3mm deep.

Immunohistochemistry:
AD 12 (a) H&E (slide 509379), AD12 (b) CD117 (slide 509352).