Female 40 years

Aggressive surface-based tumour with cortical destruction (see attached imaging).



Macroscopic description:
Tumour measures 85x46x55mm. See attached macrophoto.

IHC staining details: Nil.

FISH studies: MDM2 amplified on FISH.

Female 39 years

Surface-based tumour in patient with multiple osteochondromas (see attached imaging).



Macroscopic description:
Tumour measures 60x55mm). See attached macrophoto.

IHC staining details: None.

Female 52 years

Enbloc resection of lesion in proximal femur.



Macroscopic description:
Proximal femur en bloc resection consisting of a piece of bone 50 x 35 x 25 mm with a white tumour measuring 15 x 15 x 10 mm.

IHC staining details: None.

Female 14 years

Bone cyst right proximal tibia. ? Unicameral. See PDF. Bone curettings.



Macroscopic description:
Bone fragments 30 x 30 x 4 mm in aggregate.

IHC staining details: Not performed.

Female 74 years

History of chordoma, now partial left pelvic resection for metastatic/recurrent tumour in left posterior ilium.



Macroscopic description:
See Macro.

IHC staining details: None.

Male 72 years

History of previous thyroidectomy.



Macroscopic description:
None provided.

IHC staining details: Positive for PAX 8, TTF-1, and CK7.

Male 29 years

Post chemotherapy resection of left fibula sarcoma.



Macroscopic description:
See PDF.

IHC staining details: EWSR1 Gene rearrangement detected by FISH on previous biopsy.

Male 10 years

Pathological fracture right proximal humerus, in keeping with tumour. Core biopsy. See PDF.



Macroscopic description:
Fragments of bony tissue 10 x 9 x 2 mm.

IHC staining details: None.

Female 9 years

Larger lesion right distal tibia with pathological fracture. See PDF. Bone curettings.



Macroscopic description:
Fragments of bony tissue 40 x 40 x 10 mm in aggregate.

IHC staining details: G34W negative.

Male 56 years

Proximal phalanx fourth finger, ray amputation.



Macroscopic description:
See PDF.

IHC staining details: H3F3 G34W positive.

Male 58 years

Left anterior thigh mass, resection.



Macroscopic description:
Intramuscular solid mass measuring 10 x 100 x 95mm

IHC details: None.

Female 69 years

Right breast WLE following spindle cell tumour diagnosis on core biopsy.



Macroscopic description:
Skin ellipse 80 x 40 mm with underlying breast tissue 80 x 48 x 40 mm. On sectioning a tumour is present, measuring 21 x 22 x 26 mm.

IHC staining details: Focally positive for SMA. they are negative for AE1/3, MNF116, CK7, CAM 5.2, EMA, CK5/6, CK14, S-100, desmin, CD31, and CD34.

Male 67 years

Amputation for tumour arising from right sciatic nerve.



Macroscopic description:
See macro.

IHC staining details: Diffusely positive for S100 and SOX 10 with associated loss of INI-1 expression. Negative for Melan-A, and HMB-45.

Male 43 years

History of synovectomy right knee, now recurrent tumour.



Macroscopic description:
None provided.

IHC staining details: None provided.

Female 66 years

Neck mass, resection.



Macroscopic description:
See MRI.

IHC staining details: Very focal staining for EMA. Negative for CD34, S100, MUC4, desmin, and SMA. JAZF1::PHF1 fusion detected on biopsy.

Female 33 years

History of chromosome 5Q deletion. Left paraspinal mass , core biopsy.



Macroscopic description:
See MRI (arrows indicate lesion).

IHC staining details: Patchily positive for SMA with associated scattered cells showing nuclear positivity for B-catenin. Negative for desmin, MUC4, CD34, and S100.

Female 89 years

Left breast outer quadrant lesion, mixed echo density, core biopsy.



Macroscopic description:
2 cores of tissue, the longest 23 mm.

IHC staining details: Positive for desmin, CD34, ER, and PR, with associated focal staining for SMA. Negative for AE1/3, CK 8/18, MNF116, p63, and S100.

Female 37 years

Intramuscular right rectus medialis lesion ? Myxoma. Core biopsy.



Macroscopic description:
A single core of cream and beige coloured tissue, 16 mm long.

IHC staining details: None.

Female 33 years

Left thumb lump, excisional biopsy .? Giant cell tumour vs inclusion cyst.



Macroscopic description:
A well-defined piece of firm tissue measuring 7 mm in maximum dimension.

IHC staining details: None.

Male 68 years

Lesion in vastus lateralis muscle, excision.



Macroscopic description:
An intramuscular mucoid lesion 5 cm in maximum dimension.

IHC staining details: Positive for CD34 and patchily positive for SMA. Negative for desmin, S100, and MUC4.