Female 44 years

Hypercholesterolaemia. Hyperthyroidism. ?Steatohepatitis, biopsy to exclude autoimmune hepatitis.

Specimen:

Liver biopsy

Macroscopic description: Core of tissue measuring 1.7 cms in dimension

Female 71 years

Cirrhosis, ?cause. Hepatitis serology negative, autoimmune profile negative.

Specimen:

Liver biopsy

Macroscopic description: Four cores.

Female 35 years

Small adenoma, increasing in size, risk of HCC transformation. No cirrhosis. No hepatitis.

Specimen: Right hepatectomy

Macroscopic description: Lobe of liver weighing 405 gms and measuring 190 x 130 x 70 mm. On slicing: spherical white lesion 20 mm in diameter close to resection margin.

Female 60 years

Patient complained of mild upper right quadrant discomfort. CT scan showed a few nodules ?HCC, resulting in a partial hepatectomy.

Specimen: Liver

Macroscopic description: Left hepatectomy weighing 354 gms and measuring 150 x 90 x 40 mm. The cut surface shows four well defined yellow/brown nodules (4 mm (?4 cms) in max dimension). Microscopically all nodules had similar features to that included

Female 73 years

Cirrhosis suggested on CT scan, ascites and decreased albumin but coagulation normal. Metabolic/viral/genetic screens negative. No alcohol excess. Masson stain: severe fibrosis with many fibrous septa.

Specimen:

Liver biopsy

Macroscopic description: Four cores between 9mm and 3mm long

Female 76 years

CT showed large hepatic mass. No other tumour. Presumed primary hepatoma. (incidental ovarian fibroma at surgery - frozen section confirmed). Immunohistochemistry - positive staining with CK7, CK18, CK19, CD56. Negative staining with CK20, CDX2. CD10 and CD13 - no canalicular staining pattern alphafeto protein, non contributory (problems in lab with pos controls). Gall bladder removed - no tumour.

Specimen: Right hepatectomy

Macroscopic description: 18 x 18 x 12 cm segment of liver. Subcapsular 15 x 9 x 7 cm tumour, white. Extended close to cut margin.

Male 69 years

Haemochromatosis, raised LFTs.

Specimen:

Liver biopsy

Macroscopic description: Three cores of brown tissue

Female 68 years

Renal carcinoma, nodules on the liver surface. CK7 & CAM5.2 POSTIVE; CK20; mCEA, CE10, TTF1 negative; CA19.9 and pCEA variable.

Specimen: Liver core biopsies

Macroscopic description: Two cores of whitish tissue each measuring 10 x 2 mm.

Male 49 years

ALT 120, alcohol, +nil for 4 months

Specimen:

Liver biopsy

Macroscopic description: Patchy periportal copper associated protein on orcein

Male 66 years

?HCC, ?alcohol related liver disease

Specimen: Liver resection

Macroscopic description: 165g wedge of liver with a 10 mm irregularly contoured tan nodule

Female 53 years

PC Feb 2006. Nausea, anorexia, jaundice, pale stool and dark urine. ALT 468, alpha GT 1827, BR97, alk phos 517, ferritin 1660. Heterogenous liver on USS. Drugs - black cohosh. Alcohol 10-12 units/week. Stopped black cohosh April/May 06.

Liver biopsy Dec 2006. Hep A, B, C negative. AIP negative becoming positive ANA (1:80) in Feb 2007. LFTS now improving - no treatment given.

Specimen:

Liver biopsy

Macroscopic description: Three cores of liver.

Male 51 years

Cryptogenic cirrhosis.

Specimen: Explant liver.

Macroscopic description: Weight 1,054gms, measurement 23 x 13 x 6cms. Partial nodularity (1-6mm diameter nodules) alternating with areas of parenchymal collapse.