Female 47 years

Hepatitis C infection. Genotype 1 prior biopsy in 1998 Ishak 2 fibrosis. ?Progression alanine transaminase 1.5 x normal No IV drug history. No treatment

Male 36 years

Previous history of testicular teratoma 5 years earlier; (no record of any chemotherapy) ?adenoma, ?metastatic teratoma

Specimen: Tumour left lobe of liver

Macroscopic description: An oblong white coloured mass measuring 180 x 90 x 60 mm. Outer surface and cut surface appears nodular with soft white and partly cystic cut surface.

Female 57 years

Weight loss and jaundice. Positive smooth muscle antibody (SMA) , ?autoimmune hepatitis. Bilirubin 20, alkaline phosphatase 199 aspartate transaminase 24, Glob 32, smooth muscle antibody (SMA) +

Specimen:

Liver biopsy

Macroscopic description: Two cores measuring 12 mm each

Male 57 years

Hepatitis C positive, ?for viral therapy. Reticulin stain shows portal expansion with fibrous septa, without linkage

Specimen:

Liver biopsy

Macroscopic description: Two cores 14 and 12 mms

Female 42 years

Transjugular liver biopsy - liver biopsy, ?aetiology

Female 39 years

Anti-mitochondrial antibody strongly positive

Specimen:

Liver biopsy

Macroscopic description: 15 mm core

Female 50 years

?primary biliary cirrhosis. Antimitochondrial antibody (AMA) positive (>1.640) M2 positive, bilirubin 7, alkaline phosphatase 106, WVG - mild fibrous expansion of some portal areas only.

Specimen:

Liver biopsy

Macroscopic description: Two cores of liver

Male 53 years

Abnormal liver function tests

Specimen:

Liver biopsy

Macroscopic description: Core of tissue measuring 8 mm in length (perivenular and pericellular fibrosis)

Male 51 years

Gilbert's syndrome and sarcoidosis on steroids, abnormal liver function tests - Special stains: Perls shows increased iron in hepatocytes

Specimen: Liver needle biopsy

Macroscopic description: Core of brownish tissue 15 x 2 mm.

Male 50 years

?Methotrexate fibrosis. Increasing procollagen 3.

Specimen:

Core biopsy

Macroscopic description: One core 34 mm long

Male 57 years

Liver resection for metastatic colorectal cancer following oxaliplatin and 5FU chemotherapy. Tumours in segments 5 and 8, plus segments 2 and 3, as separate wedge resections

Specimen: Right hemihepatectomy

Macroscopic description: Segments 5-8, 740 gms, 17 x 16 x 7 cm. Contains 3 tumours 4.5 cms, 5.5 cms and 0.5 cms (2 x H & E slides)

Male 8 years

Investigated for weight loss and abnormal liver function tests . Imaging showed mass at porta hepatis.

Specimen: Liver - left trisectionectomy

Macroscopic description: 20 x 13 x 6 cm, 540 gms. 2.5 cm diameter white mass at porta hepatis, obstructing portal vein which is thrombosed