Female 8 years

Polycystic disease.

Specimen: Section from explanted liver.

Macroscopic description: Firm liver 24.5 x 14 x 8 cms.

Female 58 years

Liver nodule noted at time of organ transplantation.

Specimen: Liver wedge biopsy.

Macroscopic description: 4 mm pale tan nodule on wedge.

Female 52 years

Alcoholic liver disease - ?cirrhosis

Specimen:

Liver biopsy

Macroscopic description: Two cores of tissue up to 10 mm in length (H & E and Elastic Van Gieson (EVG) slides).

Male 65 years

History of systemic lupus erythematosus SLE and sarcoidosis - abnormal liver function tests - alkaline phosphatase 164, gamma glutamyl transferase 326, IgG 17.4, antinuclear antibody (ANA) 1:640, dsDNA >300, smooth muscle antibody positive

Specimen: Needle biopsy of liver

Macroscopic description: Core of tissue 28 mm in length

Male 55 years

Hep C RNA positive genotype I, ?for treatment

Specimen:

Core biopsy

Macroscopic description: Two cores

Male 40 years

6 cm tumour in segment 8. Probable focal nodular hyperplasia on imaging. Incidental finding

Specimen: Laparoscopic tumour resection

Macroscopic description: Several pieces of granular brown tissue up to 1.5 cms

Male 77 years

Jaundice. Special stains are negative for hepatitis B, alpha-1 antitrypsin, copper associated protein and haemosiderin

Specimen:

Core biopsy

Macroscopic description: Core of brown tissue, measuring 17 x 1 mm

Female 37 years



Liver biopsy - presented with non-specific illness/malaise ultrasound scan (USS) - multiple lesions in liver, ?hydatid cysts, ?metastases. Also has lesions in spleen

Specimen: Wedge biopsy.

Macroscopic description: Piece of tissue measuring 2.5 x 1 x 1 cm. The cut surface shows irregular white foci measuring 75 x 3.

Male 58 years

Patient with ulcerative colitis on Mesalazine (long term). Recent history of jaundice, ALT 1212; alkaline phosphatase 230; total bilirubin 29; Anti-smooth muscle antibody+++; antinuclear antibody 1:640; ferritin >2000, viral screen negative, no alcohol,

Specimen:

Liver biopsy

Macroscopic description: Two cores of liver, combined length 25 mms

Male 76 years

Previous Duke's B carcinoma of transverse colon 1 year earlier. Now has recurrence at ileo-sigmoid anastomosis. Site resected and solitary nodule, ?metastases seen in gallbladder bed and resected.

Specimen: Segment 5 of liver

Macroscopic description: 62 gm wedge of liver measuring 7 x 4.5 x 3.5 cms. White nodular lesion on cutting this measuring 2 cm diameter. Firm white appearance

Female 58 years

Abnormal liver function tests, alkaline phosphatase 253, gamma glutamyl transferase 395. Autoantibodies negative apart from smooth muscle antibodies+++ History of rheumatoid arthritis and thyroid disease.

Specimen: Liver core biopsy

Macroscopic description: 3 fragments of liver, combined length 14 mm

Male 56 years

Hepatomegaly, gamma glutamyl transferase 450, alcoholic history

Specimen:

Liver biopsy

Macroscopic description: Three tan cores of tissue from 0.7 - 2 cms