Male 45 years

Abnormal liver function test: Alkaline phosphaase 327; gamma GT 249; minimal elevation of ALT; Viral screen negative; autoantibodies negative; patient has stage 3 sarcoidosis.

Specimen:

Liver biopsy.

Macroscopic description:
2 core of liver combined length 22mm.

Immunohistochemistry:
Masson trichrome.

Male 20 years

IBD, deranged LFTs, no large duct PSC on imaging. Raised IgG, positive LCA, ? AIH/small duct PSC.

Specimen:

Liver biopsy.

Macroscopic description:


Liver biopsy - one core 30mm long.

Immunohistochemistry:
Orcein, CK7, van gieson, DPAS, reticulin.

Female 29 years

Multiple hepatic adenomas, one >6cm in size.

Specimen: Liver resection.

Macroscopic description:
Liver wedge measuring 38 x 25 x 18mm. Cut surface has a mottled and haemorrhagic cut surface.

Immunohistochemistry:
None.

Female 58 years

Acute hepatitis, ? cause. Recent Pfizer vaccine.

Specimen: Biopsy.

Macroscopic description:
30mm tan core bisected.

Immunohistochemistry:
Orcein.

Female 56 years

NASH, cirrhosis?

Specimen: Biopsy.

Macroscopic description:
Tan core 26mm bisected.

Immunohistochemistry:
HVG.

Female 48 years

Failed liver graft at 29 years, ? hilar malignancy.

Specimen: Liver explant.

Macroscopic description:
Explanted liver - explanted liver weighing 1576g and measuring 270 x 155 x 105mm. Gallbladder is absent. The capsular surface is haemorrhagic and mottled. Transverse slicing reveals a mottled tan brown cut surface with numerous cystic areas containing pus, the largest area measures 33mm maximum dimension. In the hilar region and extending into the major septae an abnormal area is present which is pale / yellow / cream appearance and appears to surround the hilar and septal structures, at least 60 mm in dimension. Representative sections taken.

Immunohistochemistry:
None.

Male 63 years

Sarcoid liver disease, recent imaging shows focal lesion.

Specimen:

Liver biopsy.

Macroscopic description:
2 cores of liver.

Immunohistochemistry:
Glypican 3, CD34, retic.

Male 44 years

Referred with likely cirrhosis (nodular liver, ascites, varices). Previous alcohol history (60-70 units/week). Caeruloplasmin <0.03 (?Wilsons).

Specimen:

Liver biopsy (H&E, sirius red, orcein and rhodanine).

Macroscopic description:
Two tan cores, 20 and 14mm long.

Immunohistochemistry:
Sirius red, orcein, rhodanine.

Female 34 years

Abnormal LFTs picked up on bloods, US abdo showed fatty liver, contracted gallbladder containing several small stones, mild splenomegaly. Admitted to hospital for jaundice, legs swelling and deranged LFTs. Clinical diagnosis impression of decompensated chronic liver disease, with ascites, Wilson's disease under investigation.

Specimen: Explanted liver (H&E, sirius red and orcein).

Macroscopic description:
Explanted liver (1256g), micronodular with yellow/green nodules.

Immunohistochemistry:
Sirius red, orcein.

Male 64 years

Liver metastases.

Specimen: Targeted liver biopsy.

Macroscopic description:
1 core 10mm and 2 fragments.

Immunohistochemistry:
Following initial assessment - not submitted for EQA

Female 65 years

?Autoimmune hepatitis, abnormal LFT's, ANA positive. AMA negative.

Specimen:

Liver biopsy.

Macroscopic description:


Liver biopsy: Two cores of cream tan tissue received measuring 19mm and 19mm both processed in 1A.

Immunohistochemistry:
Van Gieson, Victoria blue.

Male 58 years

Liver transplant for alcohol related liver disease.

Specimen: Explanted liver.

Macroscopic description:
Liver , 1240g, macronodular cirrhosis.

Immunohistochemistry:
PASD stain.