Female 51 years

Sarcoid diagnosed 2008. Subsequent Methotrexate, now stopped. GGT 137 iu/L, Alk Phos 258 iu/L, br 10 umol/L, ALT 16 iu/L. Normal Immunoglobulins. Autoimmune liver profile negative. Overweight. Splenomegaly.

Specimen: liver biopsy.

Macroscopic description:
TWO FINE PALE BROWN CORES EACH 19MM.

Immunohistochemistry:
Special stains - fungal and mycobacterial stains are negative. Focal deposition of copper associated protein noted.

Female 32 years

Liver mass on imaging.

Specimen: Liver resection segment 3.

Macroscopic description:
Wedge of liver 90 x 60 x 50mm, central fibrous scar.

Immunohistochemistry:
PSR.

Male 69 years

He has an active hepatitis C. He is now within the window period where he can now be transplanted (downstaged). Background liver biopsy to establish cirrhosis or not (as this would determine eligibility if cirrhotic).

Specimen: liver core biopsy.

Macroscopic description:


Liver biopsy background: Core of tissue 2.4cm in length bisected at 1.7cm.

Immunohistochemistry:
special stains EPSR, Perls, Reticulin, PASD, orcein.

Male 69 years

He has an active HCC. He is now within the window period where he can now be transplanted (downstaged). Background liver biopsy to establish cirrhosis or not (as this would determine eligibility if cirrhotic). Further lesional biopsy ?HCC or cholangiocarcinoma? Raised CA-19 -9.

Specimen:

Core biopsy of liver lesion.

Macroscopic description:


Liver biopsy lesion: 3 cores of tissue 7cm in total length.

Immunohistochemistry:
reticulin.

Female 38 years

?Adenoma ?Adenomyolipoma excised.

Specimen: Liver segment 5/8.

Macroscopic description:
Wedge of liver measuring 80 x 62 x 30mm containing a well demarcated pale tan coloured lesion measuring up to 54mm in maximum dimension & focally abutting the resection margin.

Immunohistochemistry:
None.

Female 61 years

Abnormal LFT's.

Specimen:

Liver biopsy.

Macroscopic description:
Two cores, 18mm and 15mm.

Immunohistochemistry:
PSR and reticulin.

Female 28 years

UC, abnormal LFTs, high ALP 231, ALT back to normal from 58-74. ? Cause of abnormal LFTs.

Specimen: liver biopsy.

Macroscopic description:
one core 26mm long.

Immunohistochemistry:
CK7, Shikata.

Male 63 years

Patient had long history of PSC and underwent liver transplantation. Imaging demonstrated filling defect at the confluence of the intrahepatic ducts and dilatation of the intrahepatic biliary system.

Specimen: Liver resection.

Macroscopic description:
3cm polypoid intraluminal lesion at the confluence of the right and left intrahepatic ducts. Section is from this lesion.

Immunohistochemistry:
N/A.

Male 58 years

Liver disease screen.

Specimen:

Liver biopsy.

Macroscopic description:
Two cores 16mm and 14mm.

Immunohistochemistry:
PSR, Perls.

Male 68 years

Cholestatic LFT's, +ve AMA.

Specimen:

Liver biopsy.

Macroscopic description:
19mm core.

Immunohistochemistry:
None.

Female 47 years

Patient with a cyst segment 4 on CT/MRI looks like a simple cyst.

Specimen: Liver cyst.

Macroscopic description:
a cyst measuring 60 x 40 x 28mm with a rim of liver at the resection margin. Slicing shows a cyst containing off-white mucoid material. The cyst lining is smooth with no solid areas.

Immunohistochemistry:
None.

Male 48 years

Transaminitis. NAFLD. methotrexate for ..... Fatty liver.

Specimen: liver biopsy.

Macroscopic description:
one core 30mm long.

Immunohistochemistry:
retic, van Gieson.

Female 67 years

Systemic mastocytosis. Declining albumin, increasing liver stiffness, ?cirrhosis ?due to ongoing mastocytosis.

Specimen:

Liver biopsy.

Macroscopic description:
3 tan cores 8,16 and 27mm largest bisected.

Immunohistochemistry:
positive CD117 mast cell tryptase.

Male 53 years

On TPN for short gut; recent hemorrhagic pancreatitis; history of alcohol excess; currently- jaundice and rising bilirubin (200-250); no biliary obstruction on imaging.

Specimen: core liver biopsy.

Macroscopic description:
3 cores of liver tissue.

Immunohistochemistry:
retic and Masson Trichrome to be provided.