Male 45 years

Deranged LFTs, increased serum ACE level.

Specimen:

Liver biopsy.

Macroscopic description:
Two cores 18mm and 16mm.

Immunohistochemistry:
None.

Female 66 years

Patient presented with jaundice and diagnosed with AIH. Trial of steroids 0 no improvement. This is a follow up biopsy.

Specimen: Transjugular liver biopsy.

Macroscopic description:
4 cores, 19,8,7 and 3mm.

Immunohistochemistry:
EPSR.

Male 59 years

Liver transplant for autoimmune hepatitis.

Specimen: Liver explant.

Macroscopic description:
Explant liver 1316g, cirrhotic appearance, no focal lesions seen.

Immunohistochemistry:
None.

Male 22 years

New acute hepatitis ? cause. Persistently elevated ALT 330 and bilirubin 150 with pruritis/jaundice/headache for several weeks. ? viral ? autoimmune. USS no duct dilatation.

Specimen:

Liver biopsy.

Macroscopic description:
One core 27mm long.

Immunohistochemistry:
Shikata, CK7, Retic, EVG.

Male 55 years

NAFLD. Fibroscan 12. Moderate fibrosis? on Humira for rheumatoid arthritis.

Specimen:

Liver biopsy.

Macroscopic description:
Tan core 31mm.

Immunohistochemistry:
HVG.

Female 80 years

Liver cirrhosis, mass lesion in segment VIII/IVa, ?HCC.

Specimen: Sement VIII/IVa segmentectomy.

Macroscopic description:
Segment of liver 70 x 68 x 35 mm containing a mass lesion 22 x 22 x 18mm.

Immunohistochemistry:
None.

Male 24 years

Portal hypertension. being assessed for TIPPS; ? cirrhosis.

Specimen:

Liver biopsy.

Macroscopic description:
Tan core 12mm.

Immunohistochemistry:
PSR, VICB.

Male 73 years

Cirrhosis. Left lateral lesion, ?HCC. Ferritin 1708. AFP 5, CEA 2, CA19-9 42. MRI liver: Established cirrhosis with associated portal hypertension. Diffuse relative high signal on in-phase sequences suggests an underlying depositional process. Segment II lesion demonstrates radiological features which are considered suspicious for HCC. Multiple further small hypervascular lesions as described - may represent regenerative/dysplastic nodules but remain indeterminate.

Specimen: Lesional liver biopsy, left lobe, presumed taken at ablation clinic.

Macroscopic description:
Two cores of cream tissue measuring 10mm and 11mm in length. Embedded in 1A.

Immunohistochemistry:
Reticulin, Perls, van Gieson, Hepato, Arginase, Glutamine Gynthetase.

Female 30 years

History of COCP.

Specimen: Left lateral liver resection.

Macroscopic description:
Incidental 13 mm well-circumscribed haemorrhagic lesion in resection for larger lesion.

Immunohistochemistry:
Nil.

Male 74 years

A1AT ?extent of fibrosis.

Specimen:

Liver biopsy.

Macroscopic description:
Single tan core 28mm bisected.

Immunohistochemistry:
PASD, HVG.

Male 66 years

Abnormal LFTs. ANCA positive. Imaging normal. ? inflammation ? cirrhosis. Additional information - presented 3 weeks ago with 2 day history of nausea and vomiting; found to have derancged liver function tests. Had taken 2 courses of flucloxacillin from GP. Usual medications: levothyroxine, simvastatin, atenolol, ranitidine. Bili 100, ALT 8787, Alk phos 193.

Specimen: Liver core biopsy.

Macroscopic description:
2 cores 10mm and 8mm.

Immunohistochemistry:
Retic, van Gieson, PASD.

Female 45 years

Two lesions LLS, left lateral segmentectomy laparoscopically. Larger ?FNH ?adenoma. Smaller ?haemangioma.

Specimen: Left lateral laparoscopic segmentectomy.

Macroscopic description:
Specimen weight: 187g. Specimen dimensions: Supero-inferior 129mm, Medio-lateral 80mm, Antero-posterior 43mm Capsule intact and shows an area of bulging on the posterolateral aspect inferiorly which measures 44 x 38 x 25mm. This is intact with a cream, tan, congested appearance. On the anterior aspect 20mm superior to this area is a second area of bulging 13 x 11mm. Larger lesion segment II, smaller lesion segment II/III.

Immunohistochemistry:
Glutamine synthetase, Keratin 7, van Gieson.