Female 57 years

? liver cirrhosis; ascites. LKM1 antibodies AMA neg; ANA neg; ASM neg mild elevation of IgM viral screen neg (HCV,HBV,HIV).

Specimen: liver cores.

Macroscopic description:
3 cores of tissue.

Immunohistochemistry:
Masson trichrome, reticulin

Female 50 years

Very raised ALT. DILI v AIH Urgent histology. Recently started Etanercept for rheumatoid arthritis. Concurrent use of Isoniazid for latent TB control. no other medication. Some viral symnptoms 1 month ago. Subsequent spike in ALT 1700, with normal function of liver ? DILI, ? AIH.

Specimen: liver biopsy.

Macroscopic description:
liver biopsy - one core 11mm long.

Immunohistochemistry:
sirius red, van Gieson, retic PASD.

Male 62 years

Heavy alcohol consumption. Risk factors for NAFLD??.

Specimen: liver biopsy.

Macroscopic description:
2 cores, 28 and 30mm.

Male 50 years

Fractured right middle finger, given co-amoxiclav. Deranged LFTs Negative NILS. ? drug induced liver injury.

Specimen: liver biopsy.

Macroscopic description:
one core 18mm long.

Immunohistochemistry:
Sirius red, reticulin, PASD.

Female 65 years

Left Hepatectomy ? HCC.

Specimen: Liver left lobe.

Macroscopic description:
Left Liver lobe weighing 238gm measuring 15.5x8x4.5cm. slicing shows a variegated tumour nodule 6.3cm dia.

Immunohistochemistry:
None.

Female 31 years

Incidental finding right upper quadrant.

Specimen: Wedge resection.

Macroscopic description:
Pedunculated nodulemeasuring 55 x 40 x 30 mm.

Immunohistochemistry:
None provided.

Male 61 years

Paracetamol overdose - liver failure.

Specimen: liver biopsy.

Macroscopic description:
one core of tissue measuring 18mm.

Immunohistochemistry:
Shikata, van Gieson, PASD

Female 49 years

Jaundice for 3 weeks, no known history of liver disease. raised calcium, cause unclear. CT/MRI suggests possible chronic liver disease with acute element, however, subacute. bilirubin 180, ALP 819, ALT 59. ?chronic liver disease ?aetiology ?subacute hepatitis. liver aetiology screen negative.

Specimen: transjugular liver biopsy.

Macroscopic description:
five cores of tissue, longest 15mm.

Immunohistochemistry:
CK7, ER, CK20, TTF1.

Female 52 years

Jaundice x 1 month. Histroy or clarithromycin over 1 month ago. Drug stopped. Liver function tests now improving. Viral screen negative (HCV,HBV,HIV, EBV). ALT 308; Alkaline phosphotase 144; MRCP normal.

Specimen: Liver core biopsies.

Macroscopic description:
3 cores of liver and short fragment.

Immunohistochemistry:
Masson tricrhome, reticulin.

Male 37 years

Known HCV and HIV positive For assessment of disease activity.

Specimen: Liver core biopsies - 2 cores.

Macroscopic description:
2 cores of liver.

Immunohistochemistry:
Masson trichrome, reticulin.

Male 59 years

Known HCV infection.

Specimen: Wedge resection.

Macroscopic description:
Wedge resection of liver with a subcapsular cream lesion 13 mm in maximum dimensions.

Immunohistochemistry:
HSA positive with canalicular pattern of staining with CD13 and pCEA.

Male 70 years

Bladder resection previously for TCC. Now liver lesion ? met.

Specimen: Segment 6 resection.

Macroscopic description:
Liver with a well circumscribed partially cystic mass with a gelatinous and haemorrhagic cut surface nodule measuring 80 x 70 mm.

Immunohistochemistry:
Patchy cytoplasmic positivity for HMB45. Negative for pancytokeratin, Desmin and SMA.