Male 68 years

Raised ferritin. Raised Transferrin Sat. Haemochromatosis screen negative. ?iron overload secondary to variant haemochromatosis. >

Specimen: Two cores, (greater than 11mm).

Macroscopic description:
2 cores, 11mm and 6mm.

Immunohistochemistry:
Perls , EVG, retic.

Male 38 years

Chronic inactive hepatitis. B carrier. Rise ALT. Reactivation or rogue mutation of virus? Additional laboratory information HepB PCR positive, HBSag +ve, HBeAg -ve (+ve in past), HepC -ve. ALT 59 iu/l, ALP 51 iu/l.

Specimen: Needle core biopsy of liver.

Macroscopic description:
2 cores, 7mm and 10mm.

Immunohistochemistry:
EVG, HepC, reticulin.

Male 52 years

Presumed cirrhosis on imaging. Risk factors for liver disease: excess alcohol, overweight. Possible SLE therefore AIH?

Specimen:

Liver biopsy.

Macroscopic description:
20mm tan core.

Immunohistochemistry:
Orcein.

Male 79 years

Two liver lesions - one malignant on MR, but not HCC on EASL. ? nature. Ablation pre-treatment biopsy.

Specimen: Targeted liver biopsy.

Macroscopic description:
One core 15mm long.

Immunohistochemistry:
None.

Male 49 years

Liver transplant for alcoholic liver disease.

Specimen: Liver explant.

Macroscopic description:
Cirrhotic liver with 5mm grey/white lesion visible at capsular surface right lobe liver.

Immunohistochemistry:
No.

Female 30 years

Lesion segment 3 liver, ?FNH.

Specimen: Segment 3 liver.

Macroscopic description:
A segment of liver measuring 60 x 38 x 32mm. Single pale circumscribed lobulated lesion 35 x 32 x 27mm. 3mm from surgical margin.

Immunohistochemistry:
None.

Female 72 years

Liver transplant for hepatitis C and HCC 11 years ago. Post transplant hepatitis C PCR positive, genotype not known. Type II diabetes High ALT. Biopsy for stage of fibrosis and ? cause of high ALT.

Specimen:

Liver biopsy.

Macroscopic description:
One core 15mm long.

Immunohistochemistry:
Reticulin and sirius red.

Female 55 years

Marked derangement of LFTs. Atypical Hx. Progressive jaundice. SMA positive, Hep E -ve.

Specimen:

Liver biopsy.

Macroscopic description:
Two cores of tissue, 16mm and 13mm.

Immunohistochemistry:
Reticulin, sirius red.

Female 54 years

RUQ pain, vomiting and jaundice. Partially resolved with recurrence of jaundice and deranged LFTs. ?autoimmune hepatitis. ANA and SMA positive, Hep E negative.

Specimen:

Liver biopsy.

Macroscopic description:
Two cores 15mm and 14mm.

Immunohistochemistry:
Reticulin, sirius red.

Female 51 years

Abnormal liver function tests. elevated alk p'ase. positive AMA; elevated IgM IgG normal.

Specimen: Liver cores.

Macroscopic description:
3 cores of liver.

Immunohistochemistry:
Reticulin, masson trichrome.

Male 21 years

R hemihepatectomy.

Specimen: Right hemihepatectomy.

Macroscopic description:
1281g hemi-hepatectomy specimen containing two tumours with variable fibrosis/ calcification, 129mm in maximum dimension. No macroscopic involvement of vessels. 5mm from resection margin. One uninvolved cystic duct node.

Immunohistochemistry:
None done.

Male 76 years

Hepatitis B, not known to be cirrhotic, but on HCC surveillance due to age and viral load. USS showed 4cm lesion. AFP is 7.

Specimen: Right hemi-hepatectomy.

Macroscopic description:
Right hepatectomy 637g, containing 50mm subcapsular white solid tumour adjacent to surgical margin. Solid material in portal vein. Meets EASL criteria for HCC.

Immunohistochemistry:
None.