Female 66 years

Hereditary haemochromatosis. For hepatic Iron overload/fibrosis.

Specimen: Liver needle core biopsy.

Macroscopic description:
2 cores of yellow and brown tissue longest measuring 15 mm in length plus fragment.

Immunohistochemistry:
Perls, Massons trichrome, Orcein.

Female 60 years

Liver segment 3 lesion. Multinodular liver ? chronic liver disease ? malignant. Further clinical information from patient's notes: Thoracic and upper abdominal lymphadenopathy, hepatosplenomegaly and multiple hepatic and splenic lesions on recent CT.

Specimen: Liver core biopsy.

Macroscopic description:
Three white/brown coloured core biopsy/s largest dimension measures 19mm in length.

Immunohistochemistry:
Retic, Victoria blue, Zn.

Female 53 years

Colorectal liver met.

Specimen: Liver resection, section of lesion.

Macroscopic description:
44g segment 3 non anatomical resection, 9mm yellow lesion.

Immunohistochemistry:
LFABP immunohistochemistry.

Female 53 years

Increased LFT (cholestatic). Further information from electronic patient records: Patient has recently been treated for colorectal cancer with chemotherapy agents, including oxaliplatin.

Specimen: Liver core biopsy.

Macroscopic description:
A friable cream and 10 core measuring 30 mm.

Immunohistochemistry:
Picrosirius Red, Reticulin.

Female 58 years

Ultrasound performed in community for abdo pain - indeterminate liver lesion. MRI has shown increase in this 24mm segment 8 lesion. LFTs and tumour markers normal. No features of chronic liver disease, cirrhosis or portal hypertension.

Specimen:

Liver biopsy.

Macroscopic description:
Two tan brown cores measuring 20 and 17mm.

Immunohistochemistry:
N/A.

Male 25 years

Liver cyst.

Specimen: Liver resection.

Macroscopic description:
Liver resection 42 x 37 x 70mm containing a 29 x 18 x 15mm uniloculated cyst.

Immunohistochemistry:
N/A.

Female 37 years

Acute hepatitis ?cause. ALT up to 1000, now reducing. All serology negative. Possibly autoimmune but from Zambia ?exotic infection. Liver screen negative. PMH HTN previous IVDU, ETOH excess.

Specimen: Liver core biopsy.

Macroscopic description:
Two cores of tan tissue which measure 11mm, 12mm with accompanying fragment measuring 3mm.

Immunohistochemistry:
Van gieson, Victoria blue.

Female 77 years

Hepatitis A persistent high LFTs.

Specimen:

Liver biopsy.

Macroscopic description:
Liver core.

Immunohistochemistry:
H&E and EPSR.

Male 46 years

Liver lesion resection.

Specimen: Liver resection.

Macroscopic description:
Liver resection 160 x 150 x 45mm containing a 126 x 102 x 30mm lesion. One representative section provided that includes interface with background.

Immunohistochemistry:
N/A.

Female 48 years

Pyrexia unknown origin, intermittent fever approximately six weeks. Bilateral lung infiltrate. Large liver, some history of alcohol excess. Unclear aetiology ?cirrhosis, ?infection, ??TB.

Specimen: Liver core biopsy.

Macroscopic description:
A core of cream tissue which measures 27mm in length.

Immunohistochemistry:
Van gieson, Retic, Glutamine synthetase.

Male 42 years

2 renal transplant for IgA nephropathy-first 2010, second 2023. Treated hep C (acquired at time of renal transplant). HTN, diabetes. Imaging shows cirrhotic liver with portal HN. NILS negative. ?MASLD serosa. Medical history: Tacrolimus, prednisolone, MMF, ramipril, amlodipine, omeprazole, metformin, gliclazide, cinacalcet, bisoprolol, atorvastatin, aspirin.

Specimen: Liver core biopsy.

Macroscopic description:
A single cream core received measuring 26 mm.

Immunohistochemistry:
Reticulin, Picrosirius red.

Male 59 years

Decompensated chronic liver disease.

Specimen: Liver explant (recipient's own liver removed at time of transplant).

Macroscopic description:
Liver explant received fixed weighing 1062g and measuring 195 x 145 x 95mm with attached gallbladder 65 x 30 containing bile and no gallstones. The parenchyma has a tan nodular appearance with nodules ranging from 2 to 5mm. No suspicious lesions are seen.

Immunohistochemistry:
PASD, perls, victoria blue, EPSR and PiZ immunohistochemistry.

Male 30 years

ANCA and ANA + Increased IgG (19) , ketamine use. Normal MRCP. ALP 800 AST 160 GGT 1200. Weight loss, increased stool frequency, no blood or mucus. Cocaine history, 12 pints lager per week.

Specimen: Biopsy.

Macroscopic description:
Liver core.

Immunohistochemistry:
HVG Rhodanine.