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EQA

Head and Neck Histopathology National EQA W - Autumn 2025







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Case 01

Male 70 years

Right lateral tongue white patch.

Specimen: Tongue.

Macroscopic description:
Mucosal biopsy.

Immunohistochemistry:
N/A.


H&E 1


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Case 02

Female 59 years

39 x 14 mm mildly expansile heterogeneous lesion in the mandible extending from the left parasymphyseal region to the level of LR5 in the right hemimandible. Mixed lytic and sclerotic appearance.

Specimen: Mandibular bone & soft tissue fragments.

Macroscopic description:
Bone & soft tissue fragment.

Immunohistochemistry:
Not done.


H&E 2


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Case 03

Male 60 years

Right and left buccal mucosa white reticular lesion, no erythema seen, no ulceration. Duration unknown, no symptoms, does not rub off. Corresponds to occlusal trauma and adjacent amalgam restorations.

Specimen: Buccal mucosa.

Macroscopic description:
One pale piece of tissue received measuring 5x3mm maximum with 2mm subcutaneous tissue.

Immunohistochemistry:
N/A.


H&E 3


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Case 04

Female 46 years

1cm diameter raised soft papillomatous fleshy growth arising from lingual gingiva of left premolar.

Specimen: Gingiva.

Macroscopic description:
Ellipse of mucosa 12 x 7 x 3mm with ulceration 5 x 5mm, bisected.

Immunohistochemistry:
N/A.


H&E 4


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Case 05

Female 76 years

Papilloma lesion on right palate adjacent to UR6, non smoker, no sinister features, history of tongue cancer.

Specimen: Excisional biopsy using a 5mm punch, right hard palate lesion.

Macroscopic description:
5 mm mucosal piece.

Immunohistochemistry:
NA.


H&E 5


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Case 06

Male 39 years

Left maxillary tissue.

Specimen: Maxilla.

Macroscopic description:
Multiple pieces of irregular cream and brown tissue 30x30x7mm.

Immunohistochemistry:
Congo red positive.


H&E 6


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Case 07

Female 28 years

Left submandibular lesion.

Specimen: Left submandibular gland.

Macroscopic description:
Unoriented submandibular gland measuring 55 x 40 x 31 mm. On slicing well-defined lesion measuring 31 x 35 x 25 mm.

Immunohistochemistry:
No.


H&E 7


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Case 08

Male 70 years

Patient presented with a 2 year history of an 'enlarged' tongue which is painful at times.

Specimen: Incisional biopsy from the right lateral tongue.

Macroscopic description:
N/A.

Immunohistochemistry:
Congo Red positive.


H&E 8


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Case 09

Male 64 years

Pigmented lesion near lower eyelid.

Specimen: Soft tissue biopsy.

Macroscopic description:
Skin & soft tissue fragment.

Immunohistochemistry:
CD31+.


H&E 9


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Case 10

Female 29 years

Right lingual nerve. Following extraction of LR8.

Specimen: Right lingual nerve.

Macroscopic description:
Soft tissue 12 x 6 x 5 mm. Bisected.

Immunohistochemistry:
None.


H&E 10


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Case 11

Female 36 years

Left carotid body tumour.

Specimen: Left neck.

Macroscopic description:
Pot contains a nodule of soft tissue measuring 28 x 24 x 10 mm. Outer surface inked black and sliced from one pole to the opposite. Slicing reveals a relatively well circumscribed lesion with a maximum diameter of 22 mm.

Immunohistochemistry:
None.


H&E 11


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Case 12

Male 74 years

History of metastatic disease. New parotid lesion.

Specimen: Parotid.

Macroscopic description:
Core biopsy.

Immunohistochemistry:
Not provided.


H&E 12


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Case 13

Female 46 years

Neck dissection and tonsillectomy.

Specimen: Right neck dissection.

Macroscopic description:
40 mm cystic mass in level 2A.

Immunohistochemistry:
Not provided.


H&E 13


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Case 14

Male 40 years

Subcutaneous lump/cyst right ear helical rim.

Specimen: Right ear biopsy.

Macroscopic description:
Firm, intact,? Cyst, 7 x 4 x 4 mm. Trisected. Cross section is solid homogenous tissue. 3 pieces, all embedded.

Immunohistochemistry:
SMA+ CD31+.


H&E 14


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Case 15

Female 43 years

No clinical information.

Specimen: Left neck.

Macroscopic description:
A fluid-filled cyst measuring 65 x 55 x 20 mm and weighing 21.1 grams. Serially sliced. Representative slices taken.

Immunohistochemistry:
N/A.


H&E 15


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Case 16

Female 35 years

Maxillary sinus mass.

Specimen: Sinonasal soft.

Macroscopic description:
Multiple fragments of tissue.

Immunohistochemistry:
None.


H&E 16


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Case 17

Male 53 years

Left glosso tonsillar sulcus.

Specimen: Left posterior-lateral tongue region.

Macroscopic description:
Tonsillar tissue.

Immunohistochemistry:
CK5+.


H&E 17


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Case 18

Male 46 years

Mass left nasal cavity and orbit.

Specimen: Nasal cavity.

Macroscopic description:
Multiple fragments of tissue measuring 10 to 24mm.

Immunohistochemistry:
N/A.


H&E 18


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