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EQA

Head and Neck Histopathology National EQA J - Autumn 2018







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Case 01

Female 71 years

White homoheneous patch on lateral border of tongue. Ex smoker ? lichen planus.

Specimen: Oral mucosa.

Macroscopic description:
-

Immunohistochemistry:
-


H&E


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Case 02

Male 58 years

Large radiolucent cyst anterior mandible; biopsy of cyst lining + brown-coloured "sludgy" contents.

Specimen: Oral - odontogenic.

Macroscopic description:
cyst wall 10 x 8 x 2mm.

Immunohistochemistry:
n/a.


H&E


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Case 03

Female 45 years

Biopsy of soft submucosal lump of left upper lip. No discharging sinus, lymphadenopathy or history of trauma.

Specimen: Oral.

Macroscopic description:
-

Immunohistochemistry:
-


H&E


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Case 04

Male 23 years

Floor of mouth bluish swelling.

Specimen: Left sublingual gland.

Macroscopic description:
Tan tissue measuring 30 x 20 x 15 mm.

Immunohistochemistry:
None.


H&E


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Case 05

Male 75 years

Fungating lesion left maxilla UL56 region. ? malignant.

Specimen: Oral mucosa.

Macroscopic description:
-

Immunohistochemistry:
-


H&E


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Case 06

Male 57 years

Excisional biopsy left tongue. Patient had biopsy of a benign white patch (frictional keratosis) at the same site 2 months previously.

Specimen: oral mucosa.

Macroscopic description:
-

Immunohistochemistry:
-


H&E


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Case 07

Male 65 years

Deep lobe parotid tumour.

Specimen: parotid.

Macroscopic description:
-

Immunohistochemistry:
-


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Case 08

Male 68 years

Tongue base tumour.

Specimen: tongue base.

Macroscopic description:
-

Immunohistochemistry:
-


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Case 09

Female 63 years

Submandibular swelling.

Specimen: salivary - submandibular.

Macroscopic description:
-

Immunohistochemistry:
-


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Case 10

Female 49 years

Excisional biopsy of an enlarged level II lymph node.

Specimen: lymph node.

Macroscopic description:
-

Immunohistochemistry:
-


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Case 11

Male 77 years

Left parotid mass, FNA C3.

Specimen: parotid.

Macroscopic description:
20mm well circumscribed oval mass.

Immunohistochemistry:
-


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Case 12

Male 69 years

Left parotid cystic lesion.

Specimen: Left parotid.

Macroscopic description:
Parotid gland weighing 15 grams and measuring 42 x 40 x 15 mm. On serial slicing of the specimen a smooth, well circumscribed cyst is revealed, this measures 27 x 30 x 15 mm. It is filled with clear fluid. Three representative sections of the cyst are taken in cassettes A to C.

Immunohistochemistry:
NA.


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Case 13

Female 80 years

Biopsy pharyngeal mass.

Specimen: pharyngeal mass.

Macroscopic description:
-

Immunohistochemistry:
-


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Case 14

Male 54 years

Right nasal cavity lesion.

Specimen: sinonasal.

Macroscopic description:
-

Immunohistochemistry:
-


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Case 15

Female 74 years

Post nasal space biopsy. AE1/3, CK5, CK7, BerEp4 and Ca125 all positive. Negative for CK20, Ca19.0, CD10, CDX2, p40, CEA, synaptophysin, chromogranin and p56.

Specimen: post nasal space.

Macroscopic description:
-

Immunohistochemistry:
Positive for AE1AE3, CK5, CK7, BerEp4, Ca125. Negative for CK20, Ca19.9, CD10, CDX-2, p40, CEA, synaptophysin, chromogranin and p63.


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Case 16

Female 79 years

Sinonasal polypoid lesion.

Specimen: sinonasal.

Macroscopic description:
-

Immunohistochemistry:
-


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Case 17

Male 16 years

Left nasopharyngeal tumour.

Specimen: Left nasopharyngeal tissue.

Macroscopic description:
A soft piece of cream and tan tissue weighing 25 grams and measuring 55 x 35 x 25 mm. The specimen is serially sliced and the cut surface has a yellow and cream, spongy cut surface.

Immunohistochemistry:
NA.


H&E


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Case 18

Male 5 years

? Thyroglossal cyst.

Specimen: Neck cyst.

Macroscopic description:
A piece of tissue measuring 43 x 15 x 14 mm. This includes a soft cream cyst measuring up to 18 mm in maximum diameter.

Immunohistochemistry:
NA.


H&E


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