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EQA

Head and Neck Histopathology National EQA E - Autumn 2016







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Case 01

Male 12 years

LRQ, radiolucent lesion, well defined with radiopaque areas.

Specimen: ODONTOGENIC.





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Case 02

Female 58 years

Ulcerated left lateral tongue lesion (60 x 30 x 15 mm) and separate left buccal mass (22 x 20 x 20 mm) resected in continuity. The lateral tongue lesion was confirmed as squamous cell carcinoma; this section is from the buccal mass.

Specimen: Buccal mass.





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Case 03

Male 54 years

2cm fungating swelling left dorsum tongue.

Specimen: MUCOSAL.

Macroscopic description:
Single fragment, a lump measuring 10 x 7 x 5mm.





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Case 04

Female 15 years

Swelling left labial sulcus. Radiolucency present on radiograph.

Specimen: bone.





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Case 05

Male 72 years

Excision lesion left hard palate, burst when excising.

Specimen: ORAL MUCOSA.

Macroscopic description:
Cystic tissue, 10 x 10 x 5mm.

Immunohistochemistry:
CK7 +, CD10 + at periphery. RCC negative, TTF1 negative. Intracytoplasmic acid and neutral mucin present.





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Case 06

Male 26 years

Cyst distal to partially erupted lower left third molar tooth. ?Paradental cyst.

Specimen: Cyst from mandible associated with tooth.

Macroscopic description:
Collapsed cyst in two parts, the larger measuring 25 x 10 mm with a thickness of 3 mm. Blocked serially and submitted in total.





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Case 07

Male 76 years

Left parotid mass.

Specimen: PAROTID.

Immunohistochemistry:
SCC on FNA. ABPAS negative, CK5/6 and p63 positive.





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Case 08

Male 54 years

Total parotidectomy with neck dissection for carcinoma of the parotid.

Specimen: PAROTID.





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Case 09

Male 26 years

Persistent enlarged lymph node in mid left Level V. PMH: Psoriasis, otherwise well. No H&N masses.

Specimen: Lymph node swelling.

Macroscopic description:
Lymph node measuring 19x12x7 mm; blocked serially and submitted as representative samples.





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Case 10

Male age unknown

Neonate, neck mass and respiratory distress.

Specimen: NECK LUMP.





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Case 11

Female 57 years

Enlarging mass in Level IV left side; 3 cm diameter. History of pT1 b superficial spreading malignant melanoma excised from left shoulder 7 years ago but FNA suggests carcinoma. No H&N masses detected. Never smoker. Open biopsy submitted.

Specimen: Neck lump, lymph node swelling.

Macroscopic description:
Nodule of pale firm soft tissue 9x7x3 mm; submitted in total.

Immunohistochemistry:
AE1/3, CK7, p16 positive. S100, Melan A, HMB45, Thyroglobulin, CEA, Chromogranin A, TTF1, Napsin A, CK20, CDX2 all negative.





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Case 12

Male 85 years

Wide local excision of skin lesion left cheek.





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Case 13

Male 29 years

Tonsil asymmetry, ?neoplasia.

Specimen: Tonsil.





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Case 14

Female 44 years

Right proptosis, right orbital, frontal, ethmoid and maxillary sinus tumour on MRI.

Specimen: PARANASAL SINUSES.

Immunohistochemistry:
CD56 +, synaptophysin patchy positivity. Chromogranin, AE1/AE3 and LCA negative.





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Case 15

Female 51 years

? rhinolith from L maxillary sinus.

Specimen: SINONASAL.





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Case 16

Female 45 years

Right jugular foramen tumour.

Specimen: ENT.

Immunohistochemistry:
Chromogranin +, S100 + peripherally, negligible MIB1 index.





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Case 17

Male 42 years

Von Hippel-Lindau syndrome with previous RCC. Resection of tumour from nasal cavity / skull base ? primary or metastasis.

Specimen: NASAL/PARANASAL.





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Case 18

Male 41 years

Hearing loss, otits media and mass in post-nasal space - biopsy site post nasal space.

Specimen: NASOPHARNYX





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