Male 67 years

Oesophagus. Dysphagia.

Macroscopic description:
Mid oesophageal tumour 45x25x15mm.

Special stains: HMB 45, S-100 and melan A positive. CD45 and MNF 116 negative

Female 90 years

Small intestine. Small bowel obstruction and perforation ? cause. Previous pT4b sigmoid adenocarcinoma.

Macroscopic description:
445mm x 26 mm small bowel. 2 areas of perfoation noted (sampled). No mucosal masses/polyps seen.

Special stains: None

Male 67 years

Appendix inflamed ? Perforation.

Macroscopic description:
Appendix 50mm x up to 25mm at the tip. Widespread serosal fibrinopurulent exudate.

Special stains: Tumour cells positive for CK7 and CEA. Very occasional cells positive for chromogranin synaptophysin and NSE. Negative for CD56 and PGP9.5

Male 1 years

Small intestine. Chronic umbilical sinus Ultra sound - no deep connections.

Macroscopic description:
Skin ellipse 10 x 6 x 2 mm with an attached solid brown polyp.

Special stains: None

Female 61 years

Anus. Defunctioned for irritable bowel, rectal stump biopsies and anal verge biopsies(= this slide). Rectum proctitis, anal verge irregular and firm.

Macroscopic description:
Piece of mucosa 12 x 5 x 4 mm, all embedded.

Special stains: No ICC was performed

Female 70 years

Stomach. Gastric lesion ? GIST.

Macroscopic description:
Piece of stomach wall with a nodule measuring 31X25X24mm which is covered by intact mucosa. The cut surface is cream white with no obvious haemorrhage or necrosis.

Special stains: Tumour cells are strongly S100 positive but CD117, DOG1, SMA, Desmin and CD34 negative

Female 27 years

Small intestine. Pelvic pain. MRI - 5 cm duplication cyst of small bowel. Cyst and attached small bowel excised. Provisional diagnosis: duplication cyst.

Macroscopic description:
Small bowel measuring 5 cm long with attached mesentery. There is a purplish-grey cyst 45 mm in maximum diameter attached to the muscularis propria. The cyst wall measures 5mm thick at its thickest. The lining is smooth and greyish brown. There is no cyst content. The small bowel mucosa is normal except for the presence of a diverticulum adjacent to the cyst. There is no apparent communication between the diverticulum and the cyst or the rest of the small bowel and the cyst. Block 1C includes the small bowel lumen, the diverticulum and the cyst.

Special stains: None

Male 79 years

Stomach. 6.8cm mass in gastric fundus on EUS.

Macroscopic description:
ellipse of gastric mucosa 7.0 x 6.5 cm with an attached circumscribed nodule 6.0cm in diameter.

Special stains: tumour cells CD117 and DOG1 positive

Female 58 years

Large intestine. Multiple polyps on colostomy stoma - done for adenocarcinoma 4 years previously.

Macroscopic description:
multiple polyps up to 2cm on stoma.

Special stains: None

Male 39 years

Small intestine. Previous history of small bowel perforation. Current admission for abdominal pain and small bowel obstruction.

Macroscopic description:
36 cms long portion of small bowel, grossly abnormal with alternating dilatations and constrictions. No evidence of perforation, fibrin exudate or creeping of mesenteric fat. The constricted areas show mucosal ulceration and thickened wall by fibrosis and oedema. No fissuring ulcers. The dilated segment is grossly unremarkable.

Special stains: ZN stain is negative. No clinical evidence of sarcoidosis or systemic vasculitis. Not a chronic NSAIDs user.

Male 22 years

Fulminant UC. Total colectomy. Clinical diagnosis: acute UC.

Macroscopic description:
The specimen comprises a large bowel segment measuring approximately 120cm in length and a piece of omental fat measuring 30 x 15 x 2cm. The mucosa appears irregular with polypoid projections in areas with the macroscopic appearance of inflammatory polyps.

Special stains: None

Female 27 years

Total colectomy. Perforated caecum - stapled off and sent separately + sealed perforation of transverse colon closed with sutures. Monoclonal antibody induced colitis.

Macroscopic description:
A - Perforated caecum: 2 cm of bowel stapled at one end with 1.5cm perforation. There are multiple ?pseudopolyps on the mucosa measuring up to 2 cm. B - Total colectomy: 75 cm large bowel with attached 2 cm terminal ileum and 6.5 x 0.5 appendix. The proximal 30 cm show large confluent ulcerations, adjacent 20 cm length of bowl with multiple ?pseudopolyps. The distal 10 cm look more or less normal. Submitted section from part B.

Special stains: None

Female 49 years

Chronic small bowel obstruction. On imaging-mid ileal stricture with proximal bowel dilatation. ?CD. ?Non-steroidal anti-inflammatory drug induced.

Macroscopic description:
Ileum: The specimen comprises ileum measuring 28cm in length with attached fat measuring 17 x 3 x 1 cm. Multiple (seven) areas of narrowing/stricturing are noted in the form of fine, circumferential web like septa measuring less than 0.3cm in length. The mucosa immediately overlying the stricture appears white and fibrosed and the adjacent mucosa unremarkable. The overlying serosa also appears unremarkable and there is no of the mucosa away from the site of the stricture. The strictures are located 8, 9.5cm, 14, 16cm, 18, and 20cm from one resection margin. No other focal lesions are seen in the background ileum.

Special stains: None

Male 61 years

Tumour obstructing at sigmoid. Gangrenous right colon. Omental deposit at transverse colon.

Macroscopic description:
A subtotal colectomy with 2 cm terminal ileum, 4 cm appendix, 90 cm of colon - dilated up to 30 cm at the caecal pole which appears to be necrotic. Multiple ulcerations with normal appearing mucosa in between. Little fat attached. No high tie identifiable as all vascular ties are same length. 30 cm from the caecal pole, there is a firm 3 cm white nodule in the omental fat. 2 cm from the distal resection margin, the bowel is stenosed over 1 cm due to an almost circumferential tumour which has infiltrated through the wall into the pericolonic fat by 3mm and may involve the peritoneal surface. Submitted section from the colon.

Special stains: None