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EQA

Endocrine EQA circulation 47






Case 1

Male 36 years

Abdominal mass. Laparoscopic adrenalectomy. Circumscribed tan lesion 25mm. No adrenal seen. (+) synaptophysin, chromogranin, CD56, GATA3, S100. (-) AE1/3, Inhibin. Patchy positive SDHB.


H&E 607027


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Case 2

Female 58 years

Incidentally detected large left adrenal tumour. Non functioning. Specimen contains adrenal gland and yellow tumour. 38mm. (+) Melana A, calretinin, inhibin, synaptophysin. (-) HMB45 Chromogranin. Ki67 = 5%.


H&E 607031


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Case 3

Female 60 years

Large Left Adrenal Tumour. Necrotic/cystic/haemorrhagic mass 110mm. No adrenal seen.


Case 4

Female 69 years

Left adrenal Tumour. Previous nepherectomy.


H&E 607059


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Case 5

Male 81 years

Left adrenal mass. Adrenal 28mm and pale lesion 12mm.


H&E 607064


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Case 6

Male 63 years

Right parathyroid tumour. Primary hyperparathyroidism, very high PTH, ?adenoma. Fatty nodule 14g, 48mm.


H&E 607068


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Case 7

Female 87 years

Thyroiditis. New lesion right thyroid anaplastic Ca ? lymphoma.


Case 8

Male 54 years

Left thyroid nodule. History of lymphoma and sarcoidosis.19g thyroid lobe with irregular firm tumour 28mm. (+) CD5, cyclin D1, CD117, bcl2, CK 5/6, CK14 (focal), EMA, CK7. (-) chromogranin, TTF1, synaptophysin, CDX2, calcitonin. Ki67 20%. P53 (30%). EBV-ISH negative.


H&E 607075


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Case 9

Male 58 years

Left thyroid nodule. (+) TTF1, PAX8. (-) MNF116, CAM5.2, STAT6, CD34, Melan A, SOX10, S100, neuroendocrine markers, PTH, calcitonin.


H&E 607077


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Case 10

Female 31 years

Total Thyroidectomy and neck dissection. Multinodular tumour in upper left lobe.18mm. Macroscopically involved lymph nodes.


H&E 607083


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Case 11

Male 72 years

Total thyroidectomy and neck Dissection. Left lobe obliterated by firm white tumour. Intraoperative frozen section of trachea (+) for tumour.


Case 12

Male 47 years

Core Biopsy Right thyroid. (+) CD20, CD10, bcl6. (-) MUM1, bcl2. ki67 100%. Isolate c-myc translocation on FISH.


Case 13

Male 43 years

Right thyroid nodule. 23g thyroid lobe with solid cream, fibrous nodule bulging at capsule, 38mm.


Case 14

Female 81 years

Total thyroidectomy. Biopsy proven metastatic differentiated thyroid carcinoma on vertebral core biopsy. Multinodular cut surface to both lobes. Largest is in left lobe. 50mm. Section of that nodule (a - 607092.svs) and adjacent tissue (b - 607122.svs).