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EQA

British Neuropathological Society EQA scheme Circulation 64





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Circulation 64 - Case 1

Male 53 years

Short history of expressive and receptive dysphasia. Left temporal lesion. IDH seq shows NO mutation.

H&E 597064


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ATRX 597065


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GFAP Glial fibrillary acid protein 597066


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Circulation 64 - Case 2

Male 72 years

Right temporal mass. EMA positive and STAT6 negative. NO TERT mutation.

H&E 597067


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Circulation 64 - Case 3

Female 52 years

Fall followed by dizziness. CT/MRI finds large cystic/vascular lesion right cerebellar hemisphere.

H&E 597068


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Circulation 64 - Case 4

Female 68 years

Right homonymous hemianopia and word finsing difficulties. Large cystic left parietal lesion.

H&E 597069


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CK07 597070


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CK20 597074


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PAX8 597077


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ER Oestrogen receptor 597081


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Circulation 64 - Case 5

Female 68 years

Seizures. MRI showed right frontotemporal tumour. IDH seq showed IDH2 mutation. TERT mutation also found.

H&E 597085


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Olig2 597091


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ATRX 597095


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IDH1 R132H 597098


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GFAP Glial fibrillary acid protein 597589


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Circulation 64 - Case 6

Female 40 years

Posterior fossa lesion.

H&E 597103


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Circulation 64 - Case 7

Male 75 years

T10/11 lesion. Intradural extramedullary.

H&E 597108


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Circulation 64 - Case 8

Male 74 years

Sellar mass. No hormone excess. PIT1 and TPIT negative.

H&E 597112


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SF1 597113


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GATA3 597117


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Panck 597120


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Circulation 64 - Case 9

Female 42 years

Lower back pain. Power intact with reduced perineal sensation. MRI - intrathecal mass behind vertebra on left side of L3.

H&E 597124


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Circulation 64 - Case 10

Female 57 years

Large right frontal temporal insular tumour. Molecular information: NO TERT mutation, NO 1p/19q co-deletion, NO +7/-10, NO CDKN2A/B loss, NO EGFR amplification. Please give most likely diagnosis based on IHC and molecular information provided.

H&E 597127


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GFAP Glial fibrillary acid protein 597133


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ATRX 597144


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IDH1 R132H 597153


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Mib 1 597170


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P53 597542


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Circulation 64 - Case 11 - Educational

Female 40 years

Progressively worsening lower limb weakness for the past 4-5 months. Some proximal upper limb weakness. Generalised aches arms and legs. EMG shows mixed neuropathy and myopathy.

H&E 597180


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Gomori 597182


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Oil Red O 597613


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Circulation 64 - Case 12 - Educational

Male 55 years

Uncontrolled seizures. Right temporal lesion. NO BRAF or IDH mutations.

H&E 597189


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Olig2 597195


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Synaptophysin 597205


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Chromogranin 597211


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GFAP Glial fibrillary acid protein 597215


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Mib 1 597219


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