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EQA

British Neuropathological Society EQA scheme Circulation 58





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Circulation 58 - Case 1

Female 55 years

Progressive LL sensory disturbance, nearly intact motor power. T12 - L1 intramedullary SOL. Mulitple pieces of tissue measuring up to 10mm.

H&E 527518


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GFAP Glial fibrillary acid protein 527523


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EMA Epithelial membrane antigen 527527


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Mib 1 527533


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Circulation 58 - Case 2

Female 49 years

Left sided weakness for 6 months. Enhancing dural based lesion. Ragged mass of cream tissue 75 x 62mm.

H&E 527537


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Circulation 58 - Case 3

Female 50 years

Treated for spinal plasmacytoma and died in ITU following acute, progressive deterioration in neurological state. The CT head scan near end of life demonstrated catastrophic haemorrhage and oedema. PM Brain with generalised brain swelling. Multiple, bilateral and well demarcated haemorrhagic lesions involving all lobes.

H&E 527538


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PAS Periodic acid Shiff 527539


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Circulation 58 - Case 4

Male 23 years

T12-L2 intradural lesion compressing the conus. Three pieces of haemorrhagic tissue, measuring 30 x 20 x 12mm.

H&E 527540


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GFAP Glial fibrillary acid protein 527541


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EMA Epithelial membrane antigen 527542


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Mib 1 527543


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Circulation 58 - Case 5

Male 19 years

Progressive cognitive decline and ataxia. Initially in for leukodystrohy but MRI showed pineal lesion with CSF dissemination. Multiple pieces of tissue, in aggregate 6mm in maximum diameter.

H&E 527544


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CD30 527545


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OCT3/4 527546


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PLAP Placental alkaline phosphatase 527547


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Circulation 58 - Case 6

Male 63 years

Acute presentation of visual field deficit, headaches and a collapse. Large right intrinsic temporal SOL. Multiple pieces of tan and cream fragments measuring 50 x 40 x 10mm.

H&E 527548


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GFAP Glial fibrillary acid protein 527549


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IDH1 R132H 527550


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ATRX 527551


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Mib 1 527552


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Circulation 58 - Case 7

Female 39 years

Left frontal brain diffuse abnormalities. No significant PMH. Several pieces of tissue altogether measuring 18 x 16 x 4mm.

H&E 527553


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GFAP Glial fibrillary acid protein 527554


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P53 527555


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IDH1 R132H 527556


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ATRX 527557


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Mib 1 527558


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Circulation 58 - Case 8

Female 45 years

Left CPA lesion. Minimal hearing in left ear and left facial numbness. Several pieces of cream and yellow tissue, 12 x 12 x 4mm.

H&E 527559


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Circulation 58 - Case 9

Female 42 years

Cerebellar SOL and right frontal SOL (current specimen). Previous history of adenocarcinoma colon. Multiple fragments of tissue measuring 80 x 80 x 10mm on aggregate.

H&E 527560


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CK07 527561


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CK20 527562


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CDX2 527563


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Circulation 58 - Case 10

Female 11 years

Transphenoidal resection of sellar lesion. Cream and brown tissue, 25 x 25 x 8mm.

H&E 527564


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Circulation 58 - Case 11

Male 38 years

HIV positive and neurological decline since starting HAAR 7. Low CD4 count. Abnormal area on brain with speckled appearance (site not specified). Four cores of tissue, ranging in diameter from 3-5mm.

H&E 527565


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Circulation 58 - Case 12

Female 15 years

Long history of intermittent neurological signs and symptoms. Hydrocephalus. CNS imaging shows a diffuse process and new lesions in pineal and cervical rootlets. Previous cortical dural biopsy negative. Biopsy of new right frontal area. Several pieces of tissue, 20 x 10 x 5mm.

H&E 527566


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GFAP Glial fibrillary acid protein 527567


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Synaptophysin 527568


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Mib 1 527569


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