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EQA

British Neuropathological Society EQA scheme Circulation 57






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Circulation 57 - Case 1

Male 55 years

Paraspinal collection with extension into cord. Blood and pus seen at operation. Additional stain information: PAS positive and Gram positive.


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Circulation 57 - Case 2

Female 61 years

Pineal region tumour, several small brown fragments measuring up to 3mm. Additional stain information: Synaptophysin postive; GFAP, EMA and chromogranin negative; MIB1 low.


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Circulation 57 - Case 3

Male 71 years

Progressive deterioration of right eye vision. Site of lesion not specified. Multiple pieces of tan coloured tissue measuring altogether 60 x 40 x 10mm. Additional stain information: EMA positive; Brachyury, STAT6, CD34 negative; MIB1 low.


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Circulation 57 - Case 4

Male 66 years

Lung cancer treated with chemotherapy. Presented with headaches and ataxia. Cerebellar mass. Additional stain information: CK7, TTF1 positive.


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Circulation 57 - Case 5

Male 74 years

Previously well, no systemic disease, Left temporal lesion. 40 x 30 x 25mm partial lobectemy specimen. Additional stain information: GFAP, ATRX (wt) and p53 positive; IDH1 negative (wt); MIB1 high.


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Circulation 57 - Case 6

Male 33 years

Seizures and right temporal tumour. Specimen measures 40 x 20 x 5mm. Additional stain information: GFAP positive; NeuN, synaptophysin and neurofilament protein positive in larger cells; IDH1 negative; MIB1 low.


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Circulation 57 - Case 7

Male 30 years

Seizures and left frontal infiltrative lesion found on MRI. Additional stain information: GFAP positive: ATRX lost; IDH1 positive (mutated); MIB1 low/moderate; NO codeletion of 1p/19q.


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Circulation 57 - Case 8

Female 35 years

Known VHL. Small, cerebellar vermis lesion - cyst with a solid component.


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Circulation 57 - Case 9

Female 48 years

Thoracic lesion, T9 extramedullary intradural SOL. Presented with worsening mobility.


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Circulation 57 - Case 10

Male 27 years

4 week history of headache. MRI showed left frontal SOL. CT - CAP negative. Additonal stain information: GFAP, p53 positive; IDH negative (wt).


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Circulation 57 - Case 11

Female 32 years

Previous pilocytic astrocytoma posterior fossa 1993. VP shunt 1995. Now presenting with neck pain with radicular pain and numbness/weakness of left arm. MRI showed a C1-2 lesion. Cytokeratin and EMA negative, MIB1 low.


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Circulation 57 - Case 12

Female 86 years

?Meningioma skull base extruding into paranasal sinuses. Biopsy from superior meatus. Additonal stain information: Synaptophysin and CD56 positive; CD34, EMA , pancytokeratin negative.


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