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EQA

BLPG EQA Round 20





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BLPG EQA Round 20 - Case 1

Male 15 years

Male born in 2008. Enlarged lymph node (left inguinal). Fever, rash and patchy lymphadenopathy.

H&E 552221


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PAX5 552222


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Kappa 552223


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Lambda 552224


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CD21 552227


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CD30 552228


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Epstein-Barr encoding region (EBER) 552332


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Bcl-6 552333


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BLPG EQA Round 20 - Case 2

Male 69 years

Male born in 1954. Known GI neuroendocrine tumour grade 2 with Liver metastasis. New base of tongue mass ?metastatic neuroendocrine tumour.

H&E 552215


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CD20 552216


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CD21 552217


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CD03 552218


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CD05 552219


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Cyclin. D1 552220


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BLPG EQA Round 20 - Case 3

Female 54 years

Female born in 1969. Right eye superior fornix cherry red lesion for about 1/12. Debulking biopsy. ? amyloid, ? lymphoma. No lymphadenopathy, no significant PMH.

H&E 553546


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Bcl-6 552106


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CD20 552107


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CD23 552109


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CD03 552111


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Ki67 (MIB-1) 552113


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CD05 552305


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CD21 552457


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BLPG EQA Round 20 - Case 4

Male 81 years

Male born in 1942. Incisional biopsy of large mass right maxilla upper right 8-3. Present for around 6 / 52. ?SCC. PMH - early dementia, Hypertension, COPD, anaemia. Ex-smoker, stopped over 20 yrs ago.

H&E 552090


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CD45 552093


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CD138 552096


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Ki67 (MIB-1) 552099


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Epstein-Barr encoding region (EBER) 552102


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CD30 552302


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Mum1 552303


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BLPG EQA Round 20 - Case 5

Female 61 years

Female born in 1961. RUIQ breast biopsy. Multiple bilateral breast masses. Hx of myeloma and stem cell transplant. U5. ? breast Ca.

H&E 552174


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Mum1 552178


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CD45 552310


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CD56 552311


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Cyclin. D1 552313


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CD38 552314


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BLPG EQA Round 20 - Case 6

Female 25 years

Female born in 1998. Core biopsy of right level 4 lymph node. Widespread lymphadenopathy in the neck. ?Lymphoma.

H&E 552339


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GATA3 552246


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CD03 552341


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Mum1 552343


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CD30 552454


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BLPG EQA Round 20 - Case 7

Female 78 years

Female born in 1945. Increased WCC ?CML ?CMML

Results of other investigations:

PERIPHERAL BLOOD: Hb 97 g/L WBC 58.10 x10^9/l Plt 119 x10^9/l MCV 90.6 fl MCH 28.5 Pg Neuts 44.5 x10^9/l Lymphs 3.5 x10^9/l Monos 3.0 x10^9/l Eos 0.0 x10^9/l Basos 0.0 x10^9/l

BM ASPIRATE:

Consistent with CMML and with some spindled cells. No excess of blasts seen. FCM: Dysplastic monocytes identified.

H&E 552236


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C-KIT (CD117) 552237


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BLPG EQA Round 20 - Case 8

Male 67 years

Male born in 1956. Occasional peripheral blast, high WCCC ? AML

Results of other investigations:

PERIPHERAL BLOOD: Hb 59 g/L WBC 150.40 x10^9/l Plt 99 x10^9/l MCV fl MCH Pg Neuts 57.0 x10^9/l Lymphs 15.0 x10^9/l Monos 3.0 x10^9/l Eos 7.5 x10^9/l Basos 0.0 x10^9/l

BM ASPIRATE:

Consistent with MDS/MPN with neutrophilia. No excess of blasts seen. FCM: 2% CD34+ blasts.

H&E 552197


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Reticulin 552199


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