This website uses cookies to allow us to see how the site is used. The cookies cannot identify you. If you continue to use this site we will assume that you are happy with this.
If you would like to know more, you can view our privacy statement here.

Close
EQA

BLPG EQA Round 11





How to adjust washed-out/too bright images in ImageScope (Use the back button to return here)


Scoring for BLPG EQA, Round 11 pdf document symbol

BLPG EQA Round 11 - Case 1

Female 86 years

Right level 5 lymph node ?lymphoma. Right cervical lymph node.

Slides submitted: H&E, CD20, CD5, CD23, MUM1 & LEF1.

Other relevant immunostain results:

Positive for: CD79a & BCL-2

Negative for: CD3, EBER, CD10, CD21, CyclinD1 and SOX-11.

Ki-67 proliferation index is up to 45%.




H&E


Open Slide with:
Website | ImageScope

CD05


Open Slide with:
Website | ImageScope

CD23


Open Slide with:
Website | ImageScope

CD20


Open Slide with:
Website | ImageScope

Mum1


Open Slide with:
Website | ImageScope

Lymphoid Enhancer Binding Factor 1 (LEF1)


Open Slide with:
Website | ImageScope

BLPG EQA Round 11 - Case 2

Female 64 years

Left parotid lesion and cervical lymph nodes.

Slides submitted: H&E, CD3, CD4, CD25, MUM1 & Ki67.

Other relevant immunostain results:

Positive for: CD5, BCL6, MUM1, CD2, CD30 & BCL-2.

Negative for: CD8, CD19, CD20, CD10, CD21, CD23, MYC, TdT, P63, ALK and EBER. Ki-67.

There was partial loss of CD7. There was focal expression of granzyme B and focal/weak expression of GATA3. A minority of cells express cyclin D1. Ki67 expression is ~70%.




H&E


Open Slide with:
Website | ImageScope

CD03


Open Slide with:
Website | ImageScope

CD04


Open Slide with:
Website | ImageScope

CD25


Open Slide with:
Website | ImageScope

Ki67 (MIB-1)


Open Slide with:
Website | ImageScope

Mum1


Open Slide with:
Website | ImageScope

BLPG EQA Round 11 - Case 3

Male 35 years

HIV pos (advanced), weight loss, splenomegaly, neutropaenia. ?Lymphoma. Cervical lymph node.

Slides submitted: H&E, CD68R (PGM1), Kappa light chain & lambda light chain.




H&E


Open Slide with:
Website | ImageScope

Kappa


Open Slide with:
Website | ImageScope

Lambda


Open Slide with:
Website | ImageScope

Phosphoglucomutase 1 (PGM1)


Open Slide with:
Website | ImageScope

BLPG EQA Round 11 - Case 4

Female 51 years

Patient with long standing widespread rash on body for 14 years. Generalised lymphadenopathy, plaques on left thigh, and nodules on chest, legs.

Slides submitted: H&E, CD3, CD4, CD25 & Ki67.

Other relevant immunostain results:

Positive for: CD2, CD5 and TCR -beta (focal).

Negative for: CD7, CD8, CD19, CD20, CD30 (most cells), CD43, CD56, CD57, CD25, FOXP3, P53, ALK & granzyme B.




H&E


Open Slide with:
Website | ImageScope

CD03


Open Slide with:
Website | ImageScope

CD04


Open Slide with:
Website | ImageScope

Ki67 (MIB-1)


Open Slide with:
Website | ImageScope

CD25


Open Slide with:
Website | ImageScope

BLPG EQA Round 11 - Case 5

Male 86 years

IgM paraprotein; Bone marrow trephine biopsy.

Slides submitted: H&E, CD20, CD5, CD138, Kappa light chain & lambda light chain.

Other relevant immunostain results:

Negative for: CD3, CD10 & cyclin D1.




H&E


Open Slide with:
Website | ImageScope

CD20


Open Slide with:
Website | ImageScope

CD138


Open Slide with:
Website | ImageScope

CD05


Open Slide with:
Website | ImageScope

Kappa


Open Slide with:
Website | ImageScope

Lambda


Open Slide with:
Website | ImageScope

BLPG EQA Round 11 - Case 6

Male 60 years

Treated CLL; Bone marrow trephine biopsy.

Slides submitted: H&E, CD15, CD30, PAX5 & EBER.

Other relevant immunostain results:

Negative for: CD20, CD3 & CD5.




H&E


Open Slide with:
Website | ImageScope

Epstein-Barr encoding region (EBER)


Open Slide with:
Website | ImageScope

CD30


Open Slide with:
Website | ImageScope

CD15


Open Slide with:
Website | ImageScope

PAX5


Open Slide with:
Website | ImageScope

BLPG EQA Round 11 - Case 7

Male 75 years

Anaemia, thrombocytopenia, and atypical cells in peripheral blood; Bone marrow trephine biopsy.

Slides submitted: H&E, CD34, Myeloperoxidase, CD42b, CD117 & CD68R (PGM1).

Marrow reticulin was grade 1/3.




H&E


Open Slide with:
Website | ImageScope

CD34


Open Slide with:
Website | ImageScope

Phosphoglucomutase 1 (PGM1)


Open Slide with:
Website | ImageScope

Platelet glycoprotein Ib alpha chain (CD42b)


Open Slide with:
Website | ImageScope

C-KIT (CD117)


Open Slide with:
Website | ImageScope

Myeloid-Specific Peroxidase (MPX)


Open Slide with:
Website | ImageScope

BLPG EQA Round 11 - Case 8

Male 60 years

Patient treated for mycosis fungoides 10 years back; now presents with pancytopenia; Bone marrow trephine biopsy.

Slides submitted: H&E, CD34, Ret40F (Glycophorin C), Myeloperoxidase, CD42b, CD117 & P53.

Marrow reticulin was focally increased (grade 1-2/3).




H&E


Open Slide with:
Website | ImageScope

C-KIT (CD117)


Open Slide with:
Website | ImageScope

Glycophorin C


Open Slide with:
Website | ImageScope

Myeloid-Specific Peroxidase (MPX)


Open Slide with:
Website | ImageScope

CD34


Open Slide with:
Website | ImageScope

P53


Open Slide with:
Website | ImageScope

Platelet glycoprotein Ib alpha chain (CD42b)


Open Slide with:
Website | ImageScope