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EQA

BLPG EQA Round 10





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BLPG EQA Round 10 - Case 1

Male 63 years

Abdominal pain and diarrhoea. (Negative stains CD3, CD5, MUM1. Ki67 25-30%).

H&E


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BCL-2


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Bcl-6


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CD10


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CD20


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CD21


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BLPG EQA Round 10 - Case 2

Male 59 years

Ulcerative necrotic gingiva lower incisor region. Treated with metronidazole with no improvement. (CD20 and CD79a focally positive/heterogeneous. OCT2 positive. Negative stains:CD3, CD5, CD15, CD10, bcl6).

H&E


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CD30


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EBV-in situ hybridisation


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Mum1


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PAX5


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BLPG EQA Round 10 - Case 3

Female 67 years

Lump in the groin. ? Lymphoma. (Negative stains: CD3, CD10 and bcl6. BCL2 and IGD positive).

H&E


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CD05


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CD20


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CD21


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Cyclin. D1


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Ki67 (MIB-1)


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SOX11


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BLPG EQA Round 10 - Case 4

Female 61 years

Presented with subcutaneous nodules left thigh. ? Lipomas. (Negative stains: CD3, CD10, bcl6, CD5, MUM1).

H&E


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BCL-2


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CD20


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CD21


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IgM


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Ki67 (MIB-1)


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Kappa


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Lambda


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BLPG EQA Round 10 - Case 5

Male 64 years

? Acute Leukaemia. No evidence of lymphadenopathy. (Negative stains: CD3, CD5, TDT, CD34, CD117, CD33, CD4, CD7, MUM1. CD79a+. KI67-100%). FISH: IGH-MYC [t(8;14)] - Positive, BCL6 (3q27) - Not rearranged, BCL2 (18q21) - Not rearranged.

H&E


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BCL-2


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Bcl-6


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CD10


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CD20


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MYC


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BLPG EQA Round 10 - Case 6

Female 46 years

Previous myeloma, now cytopenia ?MDS. (Negative stains: CD56, cytokeratins, CD61, CD79a lost in larger cells).

H&E


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CD138


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Cyclin. D1


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Kappa


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Lambda


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Mum1


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BLPG EQA Round 10 - Case 7

Female 21 years

High white cell count. Cytogenetics: t(9;22) BCR-ABL1 - Positive, consistent with a diagnosis of CML. Flow cytometry: No increase myeloid progenitors.

H&E


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CD34


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CD61


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CD71


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C-KIT (CD117)


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Myeloperoxidase (MPO) (MYEL)


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Reticulin


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BLPG EQA Round 10 - Case 8

Female 28 years

Blasts in peripheral blood. ?Leukemia. Immunostains: CD33 diffusely positive. Flow Cytometry: 68% of all WBCs are CD34+CD117+CD13+CD33+HLA-DR-CD64+MPO+ TdT- blasts/promyelocytes. Equivalent numbers of blasts/hypergranular promyelocytes are morphologically apparent consistent with APML. Cytogenetics: t(15;17) PML/RARA - Positive

H&E


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CD34


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CD61


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C-KIT (CD117)


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HLA-DR


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Myeloperoxidase (MPO) (MYEL)


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Reticulin


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