Female 60 years

CT done for lung health check. Polypoid lesion in LLL bronchus.

Specimen: LLL biopsy - multiple fragments together measuring 3 mm.

Special stains/IHC results:
Positive - S100, SOX10, CD68, Ki67 <1%. Negative - AE1/3, TTF1, synaptophysin.

Female 82 years

Left lateral back lesion.

Specimen: 4 fibrofatty pieces, 50 x 40 x 20 mm together (Block A4).

Special stains/IHC results:
Positive for VG elastic stain, Negative Beta catenin, SMM. CD34 patchy +ve in fibroblasts.

Male 35 years

Abdominal pain, diarrhoea and PR bleeding.

Specimen: Multiple colonic biopsies, A to D (Block A ).

Special stains/IHC results:
Positive silver stain (Warthin starry).

Male 84 years

Left knee TKR for osteoarthritis. ?Synovitis, inflammatory cause. ?Crystal arthropathy.

Specimen: Left knee synovial tissue with pale nodules on one surface.

Special stains/IHC results:
No crystals on polarised light. CD23, CD20 and CD5 given. CD3 negative in lesional cells, CD10, Bcl6, MUM1, CD21 and Cyclin D1 negative. CD79a, Bcl2, IgD and LEF1 positive.

Male 66 years

Small left bladder lesion at the dome of bladder. Raised PSA 7.3.

Specimen: 2 pieces of bladder tissue measuring 8 mm and 5 mm across.

Special stains/IHC results:
AE1/AE3, synaptophysin and S100 given. GATA3 positive. MNF116, Cam 5.2 and p40 negative and Ki-67 less than 1%.

Male 33 years

Dyspepsia and reflux symptoms. Stomach polyp.

Specimen: 4 gastric biopsies from upper body labelled as gastric polyp.

Special stains/IHC results:
AE1/AE3 and CD68 given.

Male 58 years

HIV Positive. HEP B positive. Discontinued antiretroviral medication for several months. Admitted for feeling unwell, and found with several purple-red lesions 8 mm on left upper arm and right forearm. ?Kaposi sarcoma. Punch biopsy of one of the lesions.

Specimen: Punch biopsy 4 mm diameter.

Special stains/IHC results:
HHV-8 positive.

Female 76 years

Capsular dissection, (R) parotid Warthin's tumour.

Specimen: Piece of nodular tan tissue weighing 5.59 grams and measuring 25 x 25 x 22 mm. The surface appears partly smooth on one side and partly ragged on the other side.

Special stains/IHC results:
None.

Female 36 years

Right lower abdominal wall. Painful scar post Caesarean section.

Specimen: Core biopsy - 3 cores of tissue ranging in size from 10 mm-27 mm in length. 1 representative block submitted for EQA

Special stains/IHC results:
None.

Male 56 years

Right testis mass. Tumour markers normal.

Specimen: Orchidectomy specimen.

Special stains/IHC results:
Calretinin(+), inhibin(+), CD99(+), B-catenin (cytoplasmic +), Melan-A (cytoplasmic +), A1/3(-), synaptophysin(-), chromogranin(-), OCT-3/4(-), PLAP(-), S100(-).

Male 40 years

Left foot, mid plantar surface. Non-specific granulomatous lesion, >8 years, ?haemangioma.

Specimen: Double curettage

Special stains/IHC results:
P63(+), EMA(+), CK7(+ in ductal elements and surrounding cells), BerEp4 & CEA (scanty, weak +).

Female 51 years

?Vulval cancer.

Specimen: (R) vulva biopsy.

Special stains/IHC results:
None.

Female 30 years

U3 nodule in right thyroid. FNA - papillary thyroid carcinoma. History of FAP.

Specimen: Thyroidectomy specimen containing multiple nodules on slicing. Largest measures 22 mm in maximum dimension.

Special stains/IHC results:
Tumour cells positive for PAX8, TTF1, ER, B-catenin. Negative for thyroglobulin, calcitonin, HBME1.

Female 63 years

Lesion right shin.

Specimen: Ellipse of skin with an ill-defined and tan coloured nodule measuring 10 mm across.

Special stains/IHC results:
HMB45 and Desmin given. MiTF, CD68 and Cathepsin K positive. S100, Melan A, SMA, H-Caldesmon, p63, PAX-8, TFE3, CD56 and AE1/AE3 negative.

Male 89 years

Suspected skin cancer right inframammary fold.

Specimen: Ellipse of skin measuring 26 x 13 x 5 mm. The epithelial surface bears an eccentric, well-defined, raised, pale keratotic nodular lesion measuring 7 x 7 x 5 mm. The lesion lies less than 2 mm from the peripheral resection margin. The resection margin is inked in black.

Special stains/IHC results:
Diffuse strong positive staining for SMA and caldesmon. Negative: HMB45, ERG, CD31, CD34, AE1/AE3, p40, CK5/6, 34BETAE12, p63, CD68, MelanA, S100, SOX10 and desmin.

Female 66 years

? Malignancy. History of breast cancer (2016) and hysterectomy for endometrial cancer. 2023 - recurrence of endometrial cancer - revision surgery + radiotherapy.

Specimen: Wedge of lung.

Special stains/IHC results:
CD10(+), bcl-2(+), ER(+), CD99(+), desmin(+), CD117(-), DOG-1(-), Melan-A(-), SOX-10(-), TTF-1(-), CD34(-).