Female 46 years

Presenting symptomatically with ulcerated/eroded right nipple. Clinically ? Paget's right nipple. Imaging: normal.

Specimen: An ellipse of skin 25 x 15 mm bearing a crusted nipple 10 mm.



Special stains/IHC results:
None.

Male 49 years

Presenting with difficulty retracting foreskin. Clinically: phimosis.

Specimen: Two portions of foreskin the largest 38 x 15 x 15 mm.

Special stains/IHC results:
None.

Male 54 years

Presenting with diarrhoea. Colonoscopy: inflamed caecum with polypoid change.

Specimen: Caecal biopsies. Two pale grey tissue fragments the largest 2 mm.

Special stains/IHC results:
IHC: none. Special stains: PAS.

Female 49 years

Rectovaginal fistula, radiologically sigmoid cancer. Previous TAHBSO for ovarian cancer.

Specimen: Vaginal biopsy.

Special stains/IHC results:
Diffuse strong positivity for CDX2 and SATB2, patchy staining for CK20. P53 mutational type. Negative CK7, PAX8, WT1, ER and PR.

Female 56 years

Resection for ovarian clear cell carcinoma arising in a haemorrhagic cyst. Incidental finding in one of the pelvic lymph nodes.

Specimen: Pelvic lymph node.

Special stains/IHC results:
None.

Female 20 years

Breastfeeding patient with a large necrotic breast mass ? abscess, ? malignancy.

Specimen: Left mastectomy (230 x 193 mm x 115 mm in maximum depth), bearing a large ulcerated exophytic fungating mass measuring 210 x 179 mm x up to 100 mm. The mass has a variegated whitish grey and yellowish cut surface with areas of haemorrhage and necrosis.



Special stains/IHC results:
None.

Male 33 years

Stricturing disease. Previous hemicolectomy.

Specimen: Small bowel resection. A segment of bowel measuring 450 mm. There is mucosal irregularity, oedema and ulceration.



Special stains/IHC results:
None.

Female 57 years

Solid mass with necrosis.

Specimen: A radical nephrectomy that is largely replaced by a tumour that measures 179 x 123 x 108 mm. Cut section is haemorrhagic with necrosis and golden yellow surface.

Special stains/IHC results:
None.

Male 30 years

? Testicular tumour. Normal markers.

Specimen: A radical orchidectomy that contains a tumour that measures 25 mm. Grey, solid with areas of haemorrhage.



Special stains/IHC results:
None.

Female 19 years

Lesion left ear.

Specimen: Skin excision - pale nodular piece of skin 12 mm.

Special stains/IHC results:
None.

Female 62 years

Lump right palm ? benign.

Specimen: Pale brown firm nodule 30 x 24 x 12 mm.



Special stains/IHC results:
None.

Female 74 years

Subcutaneous swelling right thigh overlying rectus femoris.

Specimen: Grey/yellow circumscribed tissue measuring 37 x 32 x 28 mm.

Special stains/IHC results:
S100 positive.

Female 62 years

Presenting with M3 U3 echogenic mass on right outer breast. Radiologically: Unusual ? fibrosis, ? fatty component. Patient underwent core biopsy.

Specimen: Core biopsy. Several needle cores of grey/yellow tissue the longest measures 10 mm.



Special stains/IHC results:

E-cadherin neg, ER pos 8/8, PR neg 2/8, Her 2 neg 0, MIB1 - <5%. NB. Core bx also performed under u/s control of single abnormal axillary lymph node.

Female 40 years

Emergency laparotomy. Disrupted tumour throughout abdomen and pelvis from ruptured ovarian mass, presumed endometrial carcinoma.

Specimen: TAH/BSO and omentectomy done with peritoneal biopsies. The section provided is from the endometrial tumour. The ovarian tumour shows identical morphology.



Special stains/IHC results:

Patchy staining for CK7, ER and PR and patchy staining for CDX2, AFP and Glypican 3.

Male 69 years

Paratesticular mass in hydrocele.

Specimen: Multiple pieces of tissue.



Special stains/IHC results:

Tumour is positive for calretinin, thrombomodulin. Tumour is negative for BER-Ep4, CEA, CK5/6 and HBME1.

Female 51 years

Radical hysterectomy for cervical neoplasm, maximum dimension of tumour 25 mm. Radiologically cervical neoplasm with no extrauterine disease identified.

Specimen: No details provided.



Special stains/IHC results:

Tumour cells are strongly positive with PAX-8 and CK7. There is diffuse positivity with ER and PR (PR to a lesser extent). Focal positivity with CEA and MUC6. Occasional cells positive with CDX-2. P53 wild type staining. P16 and CK20 are negative.