Male 48 years

Bilateral nasal polyps. A polypoid piece of tissue 21mm across. Special stains: None

Male 39 years

Phimosis circumcision. Foreskin 35x25x3mm with a pale thickened area 20x10mm. Special stains: none.

Male 49 years

1.5cm nodule from calf. ?pilomatrixoma ?dermatofibrosarcoma ?cyst. Skin ellipse 20x5x13mm bearing a fleshy brown nodule 15mm in diameter; underlying tissue includes a firm, partly calcified lesion. Special stains: none.

Female 78 years

Lung mass history of anterior resection for colorectal carcinoma. Lobectomy, white nodule 21mm in diameter at 35mm from the bronchial resection margin. Special stains: positive for synaptophysin and CD56 with equivocal staining for TTF-1. CK7, CK20, CDX-2 and chromogranin are negative. The Ki67 proliferation index is up to 12%.

Female 54 years

Solitary nodule lower lobe (L) thyroid FNA Thy 3f, primary hyperparathyroid. Thyroid lobectomy containing a nodule 25mm in diameter. Special stains: Positive for chromogranin but negative for synaptophysin, TTF-1, thyroglobulin and CEA.

Male 80 years

?mesothelioma. No definite asbestos exposure, CT suspicious of pleural disease. A VATS - some pleural thickening but not obvious malignancy. Multiple pieces of parietal pleura, the largest strip 40mm long. No focal lesion is seen. Special stains: Epithelioid cells are positive for AE1/AE3, calretinin and WT1 with weak positivity for CK5/6 but negativity for CEA and BerEP4.

Male 68 years

Hard infiltrate skin nasolabial line. ? cutaneous secondary, ?lymphoma. A punch biopsy of skin 4mm in diameter and 2mm in depth. Special stains: Positive for CK20, CD56 and synaptophysin.

Female 62 years

Lesion inframammary crease. Wide local excision left breast. Special stains: none.

Female 39 years

?melanoma. Ellipse of skin 38x12mm to a depth of 13mm. Special stains: none.

Female 57 years

?solitary rectal ulcer ?rectal polyp. Rectal biopsy. Special stains: none.

Male 27 years

4/12 history of relatively quickly growing mass in left masseter muscle associated with enlarged cervical nodes. Left cheek. Special stains: none.

Female 50 years

Right vulval cyst. Vulval cyst. Special stains: S100 positive. CD68 negative.

Male 51 years

?lipoma right subscapular area. Irregular fatty tissue 29x20x15mm. Special stains: CD34 positive, AE1/AE3 and S100 negative, MIB proliferation fraction low (and confined mainly to mast cells).

Female 24 years

Tuberous sclerosis. Bilateral recurrent pneumothoraces. Multiple blebs on the surface of the lung. Surface bleb, 8mm in diameter. On sectioning there are multiple thin walled cystic cavities up to 3mm in diameter. Special stains: Spindle cells are positive for HMB45, oestrogen receptor, SMA (strongly) and b-catenin (weakly) but negative for Melan-A, S100, TTF-1 and CAM5.2. Papillary cells are positive for CAM5.2 and TTF-1 but negative for the other markers listed.

Female 50 years

Multinodular retrosternal goitre - main dominant L lower lobe, hanging independent of lower lobe. Total thyroidectomy. Left and right lobes appear normal. Hanging from the left lower lobe on a thin fibrous band is a 51mm nodular with a yellow and haemorrhagic cut surface. Special stains: Spindle cells positive for S100, CD34 and vimentin with patchy HMB-45. Negative for pan-cytokeratins, desmin, SMA, TTF-1 and EMA.

Female 28 years

'Stage I cervical carcinoma' treated abroad by excision only 2014. No radiotherapy and no clinical follow up. No other history available. Punch biopsy concerning; this section is taken from follow up LLETZ. Punch biopsy IHC: Ki67 mildly raised focally, strong nuclear positivity HNF1B but ER negative in worrying glands; HNF1B negative and ER positive in background endocervical glands.