Female 68 years

Anterior resection. Carcinoma of rectum.

Macroscopic description:
Polyp in sigmoid colon away from rectal carcinoma

Male 73 years

Skin cyst.

Macroscopic description:
Soft nodular tissue

Female 49 years

Skin excision. Lump on scalp behind ear.

Macroscopic description:
Skin ellipse with underlying tissue 25x15x10mm.

Male 42 years

Soft tissue, ant maxilla. Recurrent swelling L nasolabial fold. All teeth vital. On exploration smooth lump hollowing out bone.

Macroscopic description:
fibrous fragment 7x5x5mm

Male 85 years

TURBT. Solid bladder tumour, history of small cell lung cancer and high serum PSA.

Macroscopic description:
3g of firm grey fragments

Male 72 years

Soft tissue left elbow. Two nodules on left elbow, longstanding history of joint problems.

Macroscopic description:
Two nodules with pale creamy cut surfaces measuring up to 30 and 25mm respectively

Male 51 years

Soft tissue elbow. Swelling elbow and knees ?cholesterol deposit.

Macroscopic description:
Pieces of cream and orange colored tissue 3x3x1cm

Female 70 years

Partial nephrectomy. Lower pole renal mass.

Macroscopic description:
Partial nephrectomy containing a well circumscribed yellow brown mass 20mm in diameter.

Immunohistochemistry:
lesional cells are HMB45+, SMA+, CK-

Male 66 years

Biopsy peritoneal nodules. Peritoneal malignancy. History of asbestos exposure.

Macroscopic description:
Multiple pale and haemorrhagic pieces 12mm in aggregate.

Immunohistochemistry:
Positive for CK7, CK5/6, Thrombomodulin calretinin, EMA and WT1. Negative for CK20, CDX2, CA19.9, PSA, TTF1, BerEp4, Desmin and CEA

Male 56 years

Right testis. Orchiectomy. Tumour markers normal.

Macroscopic description:
An orchiectomy specimen measuring 70x50x35mm. The spermatic cord measures 30mm. On sectioning the testis measures 40x35x35mm and contains a well circumscribed, encapulated, yellow tumour which measures 23x18x16mm. The tumour is confined to the testis and does not reach the tunica albuginea. The background testicular parenchyma appears normal.

Immunohistochemistry:
the neoplastic cells are positive for inhibin, calretinin, Melan-A and vimentin. S100, HMB45, pan-cytokeratin, PLAP, CD30 and AFP are negative. HCG is equivocal. p53 stains scanty cells and the Ki-67 proliferation index is <1%

Female 27 years

Lung. Recurrent spontaneous pneumothorax. CT shows bilateral lung cysts. Pt is in the 2nd trimester of pregnancy and recently had an emergency nephrectomy.

Macroscopic description:
Clipped wedge of lung 45mm max containing tiny nodules and microcysts.

Immunohistochemistry:
spindle cells are positive for SMA, DES, HMB45, PR, weakly +ve for ER

Male 42 years

Polyp from sigmoid.

Macroscopic description:
Dark brown polyp 27x20x13mm with stalk 7x8mm