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Teaching

Teaching Cases for 08-May-17

Medical Liver Biopsies - Dr J Wyatt











Case 1

Female 43 years

Recently returned from Bangladesh. Jaundice, high ALT


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Case 2

Female 53 years

Jaundice, high ALT 1000, bili 380 high IgG34 (n<16), smooth muscle antibodies +ve


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Case 3

Female 18 years

Tiredness, abnormal liver tests. ALT 492 (<40); alk phos 225 (70-300); bili 52 (2-21) IgG 38; Anti nuclear Antobody +ve


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Case 4

Male 63 years

Previous biopsy 3 years ago - diagnosis autoimmune hepatitis. Recent decompensation. H&E and shikata stains


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Case 5

Female 61 years

Obesity, hypertension, diabetes, low alpha 1 antitrypsin


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Case 6

Male 28 years

Hepatitis B, raised ALT, ? treat


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Case 7

Male 33 years

Hepatitis C, alcohol excess, bili 131. Positive alcohol blood level. H&E and van Gieson stains


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Case 8

Male 49 years

8 months ago had a biopsy very like case 7. Now abstinent but liver failure; transplanted - this is the explant liver


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Case 9

Female 65 years

Diabetes on insulin/hypertension. Previous open cholecystectomy. Positive smooth muscle antibodies. Imaging suggestive of cirrhosis - duct dilatation on imaging. No previous history of liver disease. Needs liver biopsy to find aetiology - NAFLD, autoimmune or secondary biliary cirrhosis


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Case 10

Male 37 years

Alcohol-related liver cirrhosis (moderate drinker). Work-up for transplant. Abstinent from alcohol?


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Case 11

Male 74 years

Hepatitis C, PCR +ve. Need to assess for further management


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Case 12

Male 37 years

Day 36 post liver transplant for alcoholic liver disease. Admitted from clinic with very abnormal LFTs. ALT 71, bili 132, alk phos 3140


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Case 13

Male 53 years

Jaundice. ? mets on ultrasound


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